Research Grade Anti-Human CD262/TNFRSF10B/DR5 Antibody (TAS266) (HT348166)

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1mg

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Overview

Catalog No.	HT348166
Description	Anti-Human CD262/TNFRSF10B/DR5 Antibody (TAS266) (HT348166) is a research-grade recombinant antibody targeting CD262. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Isotype	VHH-VHH-VHH-VHH
Clone ID	TAS266
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	TRAILR2, TRAIL-R2, Death receptor 5, CD262, DR5, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9, TRAIL receptor 2, TRICK2, TNFRSF10B, KILLER, TNF-related apoptosis-inducing ligand receptor 2
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O14763
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Background	Tumor necrosis factor receptor superfamily member 10B (CD262/TRAIL-R2) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. 1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human CD262/TNFRSF10B/DR5 Antibody (TAS266)

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HT348166-SDS-PAGE-1.jpg

Datasheet

Research Grade Anti-Human CD262/TNFRSF10B/DR5 Antibody (TAS266).pdf

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Research Grade Anti-Human CD262/TNFRSF10B/DR5 Antibody (TAS266) (HT348166)

Overview

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References

Datasheet

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