Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791) (HE024013)

Name: Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791)
Brand: abinScience
SKU: HE024013
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HE024013
Description	Anti-Human mGlyR/GPR158 Nanobody (SAA2791) (HE024013) is a alpaca monoclonal antibody detecting GPR158. Suitable for Human.
Species reactivity	Human
Applications	ELISA
Host species	Alpaca
Isotype	VHH-His
Clone ID	SAA2791
Clonality	Monoclonal
Target	G-protein coupled receptor 158, GPR158, KIAA1136, Metabotropic glycine receptor, mGlyR
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q5T848
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Metabotropic glycine receptor (mGlyR/GPR158) is a ~135 kDa protein. Metabotropic receptor for glycine that controls synapse formation and function in the brain. Acts as an atypical G-protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins. In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels. Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity. 1. Laboute, T. et al. (2023) Science (New York, N.Y.) 379, 1352-1358. PMID: 36996198 2. Hajj, M. et al. (2019) Molecular pharmacology 96, 233-246. PMID: 31189666
Note	For research use only

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Datasheet

Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791).pdf

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Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791) (HE024013)

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