Anti-PARK7 Polyclonal Antibody (HV629014)

Name: Anti-PARK7 Polyclonal Antibody
Brand: abinScience
SKU: HV629014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HV629014

Description

Anti-PARK7 Polyclonal Antibody (HV629014) is a rabbit polyclonal antibody detecting PARK7 in ELISA, IHC, WB. Suitable for Human, Bovine, Chicken, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Bos taurus, Chlorocebus aethiops, Chicken, Mesocricetus auratus, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PARK7 (Met1-Asp189).

Target

Parkinson disease protein 7, Oncogene DJ1, Parkinsonism-associated deglycase, DJ-1, PARK7, Maillard deglycase, Protein/nucleic acid deglycase DJ-1, Protein DJ-1

Purification

Purified by antigen affinity column.

Accession

Q99497

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Parkinson disease protein 7 (PARK7) is a ~19 kDa protein. Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. But this function is rebuted by other works. As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively.

1. Honbou, K. et al. (2003) The Journal of biological chemistry 278, 31380-4. PMID: 12796482

2. Clements, CM. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 15091-6. PMID: 17015834

3. Junn, E. et al. (2009) Journal of neuroscience research 87, 123-9. PMID: 18711745

4. Xiong, H. et al. (2009) The Journal of clinical investigation 119, 650-60. PMID: 19229105

5. Chen, J. et al. (2010) Human molecular genetics 19, 2395-408. PMID: 20304780

6. Richarme, G. et al. (2015) The Journal of biological chemistry 290, 1885-97. PMID: 25416785

7. Advedissian, T. et al. (2016) Biochemical and biophysical research communications 473, 87-91. PMID: 26995087

8. Matsuda, N. et al. (2017) Scientific reports 7, 12816. PMID: 28993701

9. Niki, T. et al. (2003) Molecular cancer research : MCR 1, 247-61. PMID: 12612053

10. Taira, T. et al. (2004) EMBO reports 5, 213-8. PMID: 14749723

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-PARK7 polyclonal antibody at 1ug/mL on recombinant PARK7 (Catalog No. HV629012).

References

Datasheet

Anti-PARK7 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-PARK7 Polyclonal Antibody (HV629014)

Overview

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References

Datasheet

SDS

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