Research Grade Anti-CD11a/ITGAL (huS6F1) (HB805013)

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50ug
100ug
1mg

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Datasheet

Overview

Catalog No.

HB805013

Description

Research Grade Anti-CD11a/ITGAL (huS6F1) [huS6F1] (HB805013) is a humanized monoclonal antibody detecting Integrin alpha-L in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.

Highlights

●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Host species

Humanized

Isotype

IgG2, kappa

Clone ID

huS6F1

Clonality

Monoclonal

Target

Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a, ITGAL, CD11A

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P20701

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Integrin alpha-L (CD11a/ITGAL) is a ~128 kDa protein. Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity.

1. Hermand, P. et al. (2000) The Journal of biological chemistry 275, 26002-10. PMID: 10846180

2. Shimaoka, M. et al. (2003) Cell 112, 99-111. PMID: 12526797

3. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 1676048

4. Dustin, ML. et al. (1986) Journal of immunology (Baltimore, Md. : 1950) 137, 245-54. PMID: 3086451

5. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992

6. Fraemohs, L. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 6259-64. PMID: 15528364

7. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055

8. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 15356110

9. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629

10. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 23775590

Note

For research use only