Anti-Human ABCB11 Recombinant Antibody (SAA1534) (HF994013)

Name: Anti-Human ABCB11 Recombinant Antibody (SAA1534)
Brand: abinScience
SKU: HF994013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HF994013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1534

Clonality

Monoclonal

Target

BSEP, Bile salt export pump, ABCB11, ATP-binding cassette sub-family B member 11

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O95342

RRID

Anti-Human ABCB11 Antibody (SAA1534) (abinScience Cat# HF994013, RRID:AB_3727295)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Bile salt export pump (ABCB11) is a ~146 kDa protein. Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.

1. Hayashi, H. et al. (2005) Hepatology (Baltimore, Md.) 41, 916-24. PMID: 15791618

2. Hayashi, H. et al. (2005) Biochimica et biophysica acta 1738, 54-62. PMID: 16332456

3. Yabuuchi, H. et al. (2008) Biopharmaceutics & drug disposition 29, 441-8. PMID: 18985798

4. Paulusma, CC. et al. (2009) The Journal of biological chemistry 284, 9947-54. PMID: 19228692

5. Ho, RH. et al. (2010) Pharmacogenetics and genomics 20, 45-57. PMID: 20010382

6. Kato, T. et al. (2010) Biochimica et biophysica acta 1801, 1005-12. PMID: 20398791

7. Hayashi, H. et al. (2012) Hepatology (Baltimore, Md.) 55, 1889-900. PMID: 22262466

8. Guyot, C. et al. (2014) Molecular pharmacology 85, 909-20. PMID: 24711118

9. Imagawa, K. et al. (2018) Journal of human genetics 63, 569-577. PMID: 29507376

10. Wang, L. et al. (2020) Cell research 30, 623-625. PMID: 32203132

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human ABCB11 Antibody (SAA1534)

References

Datasheet

Anti-Human ABCB11 Recombinant Antibody (SAA1534).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ABCB11 Recombinant Antibody (SAA1534) (HF994013)

Overview

Images

References

Datasheet

SDS

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