Anti-Human IGFBP3 Antibody (SAA1589) (HB776013)

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50ug
100ug
1mg

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Datasheet

Overview

Catalog No.

HB776013

Description

Anti-Human IGFBP3 Antibody (SAA1589) [SAA1589] (HB776013) is a mouse monoclonal antibody detecting IGFBP3 in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1589

Clonality

Monoclonal

Target

IBP-3, Insulin-like growth factor-binding protein 3, IGF-binding protein 3, IBP3, IGFBP-3, IGFBP3

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P17936

RRID

Anti-Human IGFBP3 Antibody (SAA1589) (abinScience Cat# HB776013, RRID:AB_3727350)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Insulin-like growth factor-binding protein 3 (IGFBP3) is a ~31 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1.

1. Liu, B. et al. (2000) The Journal of biological chemistry 275, 33607-13. PMID: 10874028

2. Cobb, LJ. et al. (2009) Molecular endocrinology (Baltimore, Md.) 23, 1624-33. PMID: 19556345

3. Ingermann, AR. et al. (2010) The Journal of biological chemistry 285, 30233-46. PMID: 20353938

4. Muzumdar, RH. et al. (2009) PloS one 4, e6334. PMID: 19623253

5. Lue, Y. et al. (2010) Endocrinology 151, 350-7. PMID: 19952275

6. Leal, SM. et al. (1997) The Journal of biological chemistry 272, 20572-6. PMID: 9252371

7. Huang, SS. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1719-21. PMID: 15371331

Note

For research use only.

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