Anti-Human TMPRSS2 Antibody (SAA2325) (HT176023)

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50ug
100ug
1mg

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Datasheet

Overview

Catalog No.

HT176023

Description

Anti-Human TMPRSS2 Antibody (SAA2325) [SAA2325] (HT176023) is a human monoclonal antibody detecting TMPRSS2 in ELISA, Inhibition. Suitable for Human.

Species reactivity

Human

Applications

ELISA, Inhibition

Host species

Human

Isotype

VHH-Fc

Clone ID

SAA2325

Clonality

Monoclonal

Target

Transmembrane protease serine 2, EC:3.4.21.122, Serine protease 10, Transmembrane protease serine 2 non-catalytic chain, Transmembrane protease serine 2 catalytic chain, TMPRSS2, PRSS10

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O15393

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Transmembrane protease serine 2 (TMPRSS2) is a ~53 kDa protein. Plasma membrane-anchored serine protease that cleaves at arginine residues. Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.

1. Bestle, D. et al. (2020) Life science alliance 3. PMID: 32703818

2. Fraser, BJ. et al. (2022) Nature chemical biology 18, 963-971. PMID: 35676539

3. Wang, H. et al. (2023) Nature communications 14, 7574. PMID: 37990007

4. McCallum, M. et al. (2024) Cell 187, 4231-4245.e13. PMID: 38964328

5. Lucas, JM. et al. (2014) Cancer discovery 4, 1310-25. PMID: 25122198

6. Wilson, S. et al. (2005) The Biochemical journal 388, 967-72. PMID: 15537383

7. Ko, CJ. et al. (2015) Cancer research 75, 2949-60. PMID: 26018085

Note

For research use only

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