Anti-TMPRSS2 Polyclonal Antibody (HT176014)

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Datasheet

Overview

Catalog No.

HT176014

Description

Anti-TMPRSS2 Polyclonal Antibody (HT176014) is a rabbit polyclonal antibody detecting TMPRSS2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TMPRSS2 (Ser284-Gly492).

Target

Serine protease 10, PRSS10, TMPRSS2, Transmembrane protease serine 2

Purification

Purified by antigen affinity column.

Accession

O15393

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Transmembrane protease serine 2 (TMPRSS2) is a ~53 kDa protein. Plasma membrane-anchored serine protease that cleaves at arginine residues. Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.

1. Bestle, D. et al. (2020) Life science alliance 3. PMID: 32703818

2. Fraser, BJ. et al. (2022) Nature chemical biology 18, 963-971. PMID: 35676539

3. Wang, H. et al. (2023) Nature communications 14, 7574. PMID: 37990007

4. McCallum, M. et al. (2024) Cell 187, 4231-4245.e13. PMID: 38964328

5. Lucas, JM. et al. (2014) Cancer discovery 4, 1310-25. PMID: 25122198

6. Wilson, S. et al. (2005) The Biochemical journal 388, 967-72. PMID: 15537383

7. Ko, CJ. et al. (2015) Cancer research 75, 2949-60. PMID: 26018085

Note

For research use only.

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