Anti-G protein Recombinant Nanobody (Nb35) (HC114013)

Name: Anti-G protein Recombinant Nanobody (Nb35)
Brand: abinScience
SKU: HC114013
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HC114013
Description	Anti-G protein Nanobody (Nb35) [Nb35] (HC114013) is a alpaca monoclonal antibody detecting G protein in Cyro-EM, X-ray Crystallography. Suitable for Human.
Species reactivity	Human
Applications	Cyro-EM, X-ray Crystallography
Host species	Alpaca
Isotype	VHH-His
Clone ID	Nb35
Clonality	Monoclonal
Target	G protein
Endotoxin level	<0.01 EU/ug
Purity	>95% as determined by SDS-PAGE.
Purification	Purified by Nickel column.
Accession	P63092
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Nanobody 35, Nanobody-35, Nb-35
Background	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short is a ~45 kDa protein. Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. 1. Pak, Y. et al. (2002) Molecular and cellular biology 22, 7942-52. PMID: 12391161 2. Gao, X. et al. (2007) The Journal of biological chemistry 282, 294-302. PMID: 17110384 3. Thiele, S. et al. (2011) Human mutation 32, 653-60. PMID: 21488135 4. Brand, CS. et al. (2015) Molecular pharmacology 88, 758-67. PMID: 26206488 5. Farfel, Z. et al. (1996) The Journal of biological chemistry 271, 19653-5. PMID: 8702665 6. Warner, DR. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 4268-72. PMID: 10200251
Note	For research use only

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Anti-G protein Recombinant Nanobody (Nb35).pdf

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Anti-G protein Recombinant Nanobody (Nb35) (HC114013)

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