Anti-Human CD355/CRTAM Antibody (5A11), PerCP (HF645147)

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Overview

Catalog No.	HF645147
Description	Anti-Human CD355/CRTAM Antibody (5A11), PerCP [5A11] (HF645147) is a mouse monoclonal antibody detecting CD355 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	5A11
Conjugation	PerCP
Clonality	Monoclonal
Target	Class-I MHC-restricted T-cell-associated molecule, Cytotoxic and regulatory T-cell molecule, CD355, CRTAM
Endotoxin level	Please contact with the lab for this information.
Accession	O95727
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Cytotoxic and regulatory T-cell molecule (CD355/CRTAM) is a ~44 kDa protein. Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation. Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity. Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production. 1. Boles, KS. et al. (2005) Blood 106, 779-86. PMID: 15811952
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD355/CRTAM Antibody (5A11), PerCP.pdf

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Anti-Human CD355/CRTAM Antibody (5A11), PerCP (HF645147)

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