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Anti-Mouse CD248 Antibody (G78), PerCP (MV681147)

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Overview

Catalog No.	MV681147
Description	Anti-Mouse CD248 Antibody (G78), PerCP [G78] (MV681147) is a human monoclonal antibody detecting CD248 in ELISA, FCM. Suitable for Human and Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human, Mouse
Applications	ELISA, FCM
Host species	Human
Isotype	IgG1, lambda
Clone ID	G78
Conjugation	PerCP
Clonality	Monoclonal
Target	Endosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248
Endotoxin level	Please contact with the lab for this information.
Accession	Q91V98
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Endosialin (CD248) is a ~81 kDa protein. Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory responses in macrophages by favoring production of proinflammatory cytokines. 1. Opavsky, R. et al. (2001) The Journal of biological chemistry 276, 38795-807. PMID: 11489895 2. Naylor, AJ. et al. (2014) PloS one 9, e107146. PMID: 25243742 3. Benedet, PO. et al. (2024) EBioMedicine 99, 104906. PMID: 38061240 4. Hong, YK. et al. (2019) The Journal of investigative dermatology 139, 2204-2214.e7. PMID: 30986375 5. Kapopara, PR. et al. (2021) Journal of thrombosis and haemostasis : JTH 19, 1932-1947. PMID: 33830628 6. Cheng, TL. et al. (2021) Translational research : the journal of laboratory and clinical medicine 232, 150-162. PMID: 33737161
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Datasheet

Anti-Mouse CD248 Antibody (G78), PerCP.pdf

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Anti-Mouse CD248 Antibody (G78), PerCP