Anti-HCV NS1/gp68/gp70/Envelope glycoprotein E2 Antibody (D04) (VK681143)

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50ug
100ug
1mg

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Datasheet

Overview

Catalog No.

VK681143

Description

Anti-HCV NS1/gp68/gp70/Envelope glycoprotein E2 Antibody (D04) [D04] (VK681143) is a human monoclonal antibody detecting Envelope glycoprotein E2 in ELISA, Neutralization.

Species reactivity

Hepatitis C virus genotype 1a (isolate H77) (HCV)

Applications

ELISA, Neutralization

Host species

Human

Isotype

IgG1, kappa

Clone ID

D04

Clonality

Monoclonal

Target

NS1, gp68, gp70, Envelope glycoprotein E2, Genome polyprotein

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P27958

RRID

Anti-HCV NS1/gp68/gp70/Envelope glycoprotein E2 Antibody (D04) (abinScience Cat# VK681143, RRID:AB_3725294)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Genome polyprotein (NS1/gp68) is a ~327 kDa protein. Packages viral RNA to form a viral nucleocapsid, and promotes virion budding (Probable). Participates in the viral particle production as a result of its interaction with the non-structural protein 5A. Binds RNA and may function as a RNA chaperone to induce the RNA structural rearrangements taking place during virus replication. Modulates viral translation initiation by interacting with viral IRES and 40S ribosomal subunit. Affects various cell signaling pathways, host immunity and lipid metabolism (Probable).

1. Ivanyi-Nagy, R. et al. (2008) Nucleic acids research 36, 712-25. PMID: 18033802

2. Anjum, S. et al. (2013) Molecular medicine reports 8, 487-92. PMID: 23799612

3. Kittlesen, DJ. et al. (2000) The Journal of clinical investigation 106, 1239-49. PMID: 11086025

4. Waggoner, SN. et al. (2007) Journal of leukocyte biology 82, 1407-19. PMID: 17881511

5. Ruggieri, A. et al. (2003) Virus research 97, 103-10. PMID: 14602201

Note

For research use only.

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