Anti-HCV NS1/Envelope glycoprotein E2 Reference Antibody (MBL-HCV1, RUO) (VK681016)

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Spec:

100ug
1mg

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SDS

Overview

Catalog No.	VK681016
Description	Anti-HCV NS1/Envelope glycoprotein E2 (MBL-HCV1) (VK681016) is a research-grade recombinant antibody targeting NS1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Hepatitis C Virus (HCV)
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Clone ID	MBL-HCV1
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	NS1, gp68, gp70, Envelope glycoprotein E2, Genome polyprotein
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P27958
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	MBL-HCV1, MBLHCV1
Background	Genome polyprotein (NS1/gp68) is a ~327 kDa protein. Packages viral RNA to form a viral nucleocapsid, and promotes virion budding (Probable). Participates in the viral particle production as a result of its interaction with the non-structural protein 5A. Binds RNA and may function as a RNA chaperone to induce the RNA structural rearrangements taking place during virus replication. Modulates viral translation initiation by interacting with viral IRES and 40S ribosomal subunit. Affects various cell signaling pathways, host immunity and lipid metabolism (Probable). 1. Ivanyi-Nagy, R. et al. (2008) Nucleic acids research 36, 712-25. PMID: 18033802 2. Anjum, S. et al. (2013) Molecular medicine reports 8, 487-92. PMID: 23799612 3. Kittlesen, DJ. et al. (2000) The Journal of clinical investigation 106, 1239-49. PMID: 11086025 4. Waggoner, SN. et al. (2007) Journal of leukocyte biology 82, 1407-19. PMID: 17881511 5. Ruggieri, A. et al. (2003) Virus research 97, 103-10. PMID: 14602201
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Western blot

Western blot analysis was performed using anti-glycoprotein E2 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant hepatitis C virus (Catalog No: VK681011)
Lane 2: negative control
Bioactivity

Detects recombinant HCV NS1/gp68/gp70/Envelope glycoprotein E2 (Catalog No: VK681011) in indirect ELISA