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Research Grade Anti-Human IL11 Antibody (Enx108A) (HB978036)

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Research Grade Anti-Human IL11 Antibody (Enx108A)

Research Grade Anti-Human IL11 Antibody (Enx108A)

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100ug
1mg

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Datasheet

Overview

Catalog No.	HB978036
Description	Anti-Human IL11 Antibody (Enx108A) (HB978036) is a research-grade recombinant antibody targeting Adipogenesis inhibitory factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4
Clone ID	Enx108A
Expression system	Mammalian Cells
Target	Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P20809
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	Enx108A, ENX108A, ENX-108A
Background	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human IL11 Antibody (Enx108A)

References

Datasheet

Research Grade Anti-Human IL11 Antibody (Enx108A).pdf

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Research Grade Anti-Human IL11 Antibody (Enx108A)