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Recombinant Human TMEFF1 Protein, N-His (HP664012)

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Recombinant Human TMEFF1 Protein, N-His

Recombinant Human TMEFF1 Protein, N-His

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Datasheet

Overview

Catalog No.	HP664012
Description	Recombinant Human TMEFF1 Protein, N-His (HP664012). Purity: >90% as determined by SDS-PAGE.. Highlights ●High Purity — >90% as determined by SDS-PAGE.
Accession	Q8IYR6
Protein length	Gly86-Glu302
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C9orf2, H7365, TMEFF1, TR-1, Tomoregulin-1, Transmembrane protein with EGF-like and one follistatin-like domain
Background	Tomoregulin-1 is a ~40 kDa protein. Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry. Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent. Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane. Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors. May be a tumor suppressor in brain cancers. 1. Dai, Y. et al. (2024) Nature 632, 383-389. PMID: 39048823 2. Chan, YH. et al. (2024) Nature 632, 390-400. PMID: 39048830 3. Gery, S. et al. (2003) Oncogene 22, 2723-7. PMID: 12743596
Note	For research use only

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SDS-PAGE

SDS-PAGE for Recombinant Human TMEFF1 Protein, N-His

References

HP664012-SDS-PAGE-1.jpg

Datasheet

Recombinant Human TMEFF1 Protein, N-His.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

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V₁ (Stock Vol.)

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Working Solution

C₂ (Working Conc.)

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Recombinant Human TMEFF1 Protein, N-His