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InVivoMAb Anti-Human CD110/TPOR Antibody (14F12) (HW601020)

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InVivoMAb Anti-Human CD110/TPOR Antibody (14F12)

InVivoMAb Anti-Human CD110/TPOR Antibody (14F12)

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100ug
1mg

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Overview

Catalog No.	HW601020
Description	InVivoMAb Anti-Human CD110/TPOR Antibody (14F12) [14F12] (HW601020) is a human monoclonal antibody detecting TPO-R in Agonist, ELISA. Suitable for Human.
Species reactivity	Human
Applications	Agonist, ELISA
Host species	Human
Isotype	IgG1
Clone ID	14F12
Clonality	Monoclonal
Target	TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q62386
RRID	InVivoMAb Anti-Human CD110/TPOR Antibody (14F12) (abinScience Cat# HW601020, RRID:AB_3729662)
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Interleukin-17A (CD110/TPOR) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. 1. Liang, SC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 7791-9. PMID: 18025225 2. Ishigame, H. et al. (2009) Immunity 30, 108-19. PMID: 19144317 3. Lee, JS. et al. (2015) Immunity 43, 727-38. PMID: 26431948 4. Park, H. et al. (2005) Nature immunology 6, 1133-41. PMID: 16200068 5. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633 6. Chen, K. et al. (2016) Cell host & microbe 20, 596-605. PMID: 27923703
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for InVivoMAb Anti-Human CD110/TPOR Antibody (14F12)

References

Datasheet

InVivoMAb Anti-Human CD110/TPOR Antibody (14F12).pdf

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InVivoMAb Anti-Human CD110/TPOR Antibody (14F12)