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InVivoMAb Anti-Mouse IL17A Antibody (BZN035) (MS856010)

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InVivoMAb Anti-Mouse IL17A Antibody (BZN035)

InVivoMAb Anti-Mouse IL17A Antibody (BZN035)

InVivoMAb Anti-Mouse IL17A Antibody (BZN035)

InVivoMAb Anti-Mouse IL17A Antibody (BZN035)

InVivoMAb Anti-Mouse IL17A Antibody (BZN035)

InVivoMAb Anti-Mouse IL17A Antibody (BZN035)

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100ug
1mg

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Overview
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References
Datasheet

Overview

Catalog No.	MS856010
Description	InVivoMAb Anti-Mouse IL17A Antibody (BZN035) [BZN035] (MS856010) is a mouse monoclonal antibody detecting CTLA-8 in FCM, Neutralization. Suitable for Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	FCM, Neutralization
Host species	Mouse
Isotype	IgG2a
Clone ID	BZN035
Clonality	Monoclonal
Target	CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL-17A, IL17A, CTLA8, IL-17, Interleukin-17A
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q62386
RRID	InVivoMAb Anti-Mouse IL17A Antibody (BZN035) (abinScience Cat# MS856010, RRID:AB_3727076)
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Interleukin-17A (IL17A) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. IL17A is the therapeutic target of secukinumab (Cosentyx). 1. Liang, SC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 7791-9. PMID: 18025225 2. Ishigame, H. et al. (2009) Immunity 30, 108-19. PMID: 19144317 3. Lee, JS. et al. (2015) Immunity 43, 727-38. PMID: 26431948 4. Park, H. et al. (2005) Nature immunology 6, 1133-41. PMID: 16200068 5. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633 6. Chen, K. et al. (2016) Cell host & microbe 20, 596-605. PMID: 27923703
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Mouse IL17A Antibody (BZN035).
Bioactivity

Detects Mouse IL17A in indirect ELISAs.
Bioactivity

SEC-HPLC detection for InVivoMAb Anti-Mouse IL17A Antibody (BZN035).

References

MS856010-SDS-PAGE-1.jpg

Datasheet

InVivoMAb Anti-Mouse IL17A Antibody (BZN035).pdf

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InVivoMAb Anti-Mouse IL17A Antibody (BZN035)