Anti-Human MAPK10 Polyclonal Antibody (HX886014)

Name: Anti-Human MAPK10 Polyclonal Antibody
Brand: abinScience
SKU: HX886014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HX886014

Description

Anti-Human MAPK10 Polyclonal Antibody (HX886014) is a rabbit polyclonal antibody detecting MAPK10. Suitable for Mouse, Rat, and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MAPK10 (Val30-Asn407).

Target

EC:2.7.11.24, JNK3, JNK3A, MAP kinase 10, MAP kinase p49 3F12, MAPK 10, MAPK10, Mitogen-activated protein kinase 10, PRKM10, SAPK1B, SAPK1b, Stress-activated protein kinase 1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P53779

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Mitogen-activated protein kinase 10 (MAPK10) is a ~52 kDa protein. Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis.

1. Yoshitane, H. et al. (2012) EMBO reports 13, 455-61. PMID: 22441692

2. Huang, J. et al. (2012) Nature 482, 542-6. PMID: 22327296

Note

For research use only

Images

References

Datasheet

Anti-Human MAPK10 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human MAPK10 Polyclonal Antibody (HX886014)

Overview

Images

References

Datasheet

SDS

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