Human MAPK10 Recombinant Protein (N-His) (HX886022)

Name: Human MAPK10 Recombinant Protein (N-His)
Brand: abinScience
SKU: HX886022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HX886022
Description	Recombinant Human MAPK10 Protein, N-His (HX886022) expressed in E. coli, spanning Val30-Asn407. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P53779
Protein length	Val30-Asn407
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	45.98 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.7.11.24, JNK3, JNK3A, MAP kinase 10, MAP kinase p49 3F12, MAPK 10, MAPK10, Mitogen-activated protein kinase 10, PRKM10, SAPK1B, SAPK1b, Stress-activated protein kinase 1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3
Background	Mitogen-activated protein kinase 10 is a ~52 kDa protein. Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. 1. Yoshitane, H. et al. (2012) EMBO reports 13, 455-61. PMID: 22441692 2. Huang, J. et al. (2012) Nature 482, 542-6. PMID: 22327296
Note	For research use only

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SDS-PAGE for Human MAPK10 Recombinant Protein (N-His)

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Datasheet

Human MAPK10 Recombinant Protein (N-His).pdf

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Human MAPK10 Recombinant Protein (N-His) (HX886022)

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