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Research Grade Anti-Human HAMP/Hepcidin Antibody (Ludwig-Maximilians U. anti_Hepsin) (HX911036)

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Research Grade Anti-Human HAMP/Hepcidin Antibody (Ludwig-Maximilians U. anti_Hepsin)

Research Grade Anti-Human HAMP/Hepcidin Antibody (Ludwig-Maximilians U. anti_Hepsin)

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100ug
1mg

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Overview

Catalog No.	HX911036
Description	Anti-Human HAMP/Hepcidin Antibody (Ludwig-Maximilians U. anti_Hepsin) (HX911036) is a research-grade recombinant antibody targeting Putative liver tumor regressor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	Ludwig-Maximilians U. anti_Hepsin
Expression system	Mammalian Cells
Target	Putative liver tumor regressor, HEPC, LEAP-1, Liver-expressed antimicrobial peptide 1, PLTR, Hepcidin, LEAP1, Hepc25, Hepc20, HAMP
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P81172
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Background	Hepcidin (HAMP) is a ~9 kDa protein. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. 1. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227 2. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594 3. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342 4. Ganz, T. et al. (2012) Biochimica et biophysica acta 1823, 1434-43. PMID: 22306005
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human HAMP/Hepcidin Antibody (Ludwig-Maximilians U. anti_Hepsin)

References

Datasheet

Research Grade Anti-Human HAMP/Hepcidin Antibody (Ludwig-Maximilians U. anti_Hepsin).pdf

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Research Grade Anti-Human HAMP/Hepcidin Antibody (Ludwig-Maximilians U. anti_Hepsin)