Human TRAF2 Recombinant Protein (N-His) (HD968012)

Name: Human TRAF2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD968012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD968012
Description	Recombinant Human TRAF2 Protein, N-His (HD968012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q12933
Protein length	Ser348-Leu501
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	E3 ubiquitin-protein ligase TRAF2, EC:2.3.2.27, RING-type E3 ubiquitin transferase TRAF2, TNF receptor-associated factor 2, TRAF2, TRAP3, Tumor necrosis factor type 2 receptor-associated protein 3
Background	TNF receptor-associated factor 2 is a ~55 kDa protein. E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. 1. Baud, V. et al. (1999) Genes & development 13, 1297-308. PMID: 10346818 2. Chadee, DN. et al. (2002) Molecular and cellular biology 22, 737-49. PMID: 11784851 3. Trompouki, E. et al. (2003) Nature 424, 793-6. PMID: 12917689 4. He, L. et al. (2004) The Journal of biological chemistry 279, 55855-65. PMID: 15383523 5. Blackwell, K. et al. (2009) Molecular and cellular biology 29, 303-14. PMID: 18981220 6. Li, S. et al. (2009) Molecular cell 33, 30-42. PMID: 19150425 7. Yin, Q. et al. (2009) Biochemistry 48, 10558-67. PMID: 19810754 8. Sondarva, G. et al. (2010) Cell research 20, 89-98. PMID: 19918265 9. Li, S. et al. (2010) Molecular and cellular biochemistry 338, 11-7. PMID: 19937093 10. Sasai, M. et al. (2010) Molecular immunology 47, 1283-91. PMID: 20047764
Note	For research use only

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Datasheet

Human TRAF2 Recombinant Protein (N-His).pdf

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Human TRAF2 Recombinant Protein (N-His) (HD968012)

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