Anti-Human TMPRSS2 Recombinant Nanobody (SAA2324) (HT176013)

Name: Anti-Human TMPRSS2 Recombinant Nanobody (SAA2324)
Brand: abinScience
SKU: HT176013
Price: 191 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HT176013

Description

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Anti-Human TMPRSS2 Nanobody (SAA2324) [SAA2324] (HT176013) is a human monoclonal antibody detecting TMPRSS2 in ELISA, Inhibition. Suitable for Human.

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Species reactivity

Alpaca

Applications

ELISA, Inhibition

Host species

Human

Isotype

VHH-His

Clone ID

SAA2324

Clonality

Monoclonal

Target

Transmembrane protease serine 2, EC:3.4.21.122, Serine protease 10, Transmembrane protease serine 2 non-catalytic chain, Transmembrane protease serine 2 catalytic chain, TMPRSS2, PRSS10

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column

Accession

O15393

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Transmembrane protease serine 2 (TMPRSS2) is a ~53 kDa protein. Plasma membrane-anchored serine protease that cleaves at arginine residues. Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.

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1. Bestle, D. et al. (2020) Life science alliance 3. PMID: 32703818

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2. Fraser, BJ. et al. (2022) Nature chemical biology 18, 963-971. PMID: 35676539

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3. Wang, H. et al. (2023) Nature communications 14, 7574. PMID: 37990007

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4. McCallum, M. et al. (2024) Cell 187, 4231-4245.e13. PMID: 38964328

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5. Lucas, JM. et al. (2014) Cancer discovery 4, 1310-25. PMID: 25122198

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6. Wilson, S. et al. (2005) The Biochemical journal 388, 967-72. PMID: 15537383

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7. Ko, CJ. et al. (2015) Cancer research 75, 2949-60. PMID: 26018085

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Note

For research use only

Images

References

Datasheet

Anti-Human TMPRSS2 Recombinant Nanobody (SAA2324).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human TMPRSS2 Recombinant Nanobody (SAA2324) (HT176013)

Overview

Images

References

Datasheet

SDS

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