Anti-Kv1.2 K+ channel Recombinant Antibody (K14/16) (HB859013)

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Overview

Catalog No.

HB859013

Description

Anti-Kv1.2 K+ channel Antibody (K14/16) [K14/16] (HB859013) is a mouse monoclonal antibody detecting Voltage-gated potassium channel subunit Kv1.2 in IHC, WB.

Applications

IHC, WB

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

K14/16

Clonality

Monoclonal

Target

Voltage-gated K(+) channel HuKIV, Voltage-gated potassium channel subunit Kv1.2, NGK1, KCNA2, Potassium voltage-gated channel subfamily A member 2, Voltage-gated potassium channel HBK5

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16389

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Potassium voltage-gated channel subfamily A member 2 (KCNA2/Kv1.2 K+ channel) is a ~56 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel.

1. Imbrici, P. et al. (2000) Pflugers Archiv : European journal of physiology 441, 257-62. PMID: 11211111

2. Ramaswami, M. et al. (1990) Molecular and cellular neurosciences 1, 214-23. PMID: 19912772

3. Lee, JH. et al. (2013) Neuroscience letters 548, 143-8. PMID: 23769686

4. Po, S. et al. (1993) Circulation research 72, 1326-36. PMID: 8495559

5. Chen, P. et al. (2010) The Journal of biological chemistry 285, 14882-14889. PMID: 20220134

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Kv1.2 K+ channel Antibody (K14/16)

References

Datasheet

Anti-Kv1.2 K+ channel Recombinant Antibody (K14/16).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Kv1.2 K+ channel Recombinant Antibody (K14/16) (HB859013)

Overview

Images

References

Datasheet

SDS

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