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Anti-Mouse PPARGC1A Polyclonal Antibody (MP446014)

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Overview
Catalog No.MP446014
Description
Anti-Mouse PPARGC1A Polyclonal Antibody (MP446014) is a rabbit polyclonal antibody detecting peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b; Ppargc1a. Suitable for Rat, Human, and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse PPARGC1A (Pro529-Arg797).
Target peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b; Ppargc1a
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O70343
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a ~90 kDa protein. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program.

1. Puigserver, P. et al. (2003) Nature 423, 550-5. PMID: 12754525
2. Rodgers, JT. et al. (2005) Nature 434, 113-8. PMID: 15744310
3. Ruas, JL. et al. (2012) Cell 151, 1319-31. PMID: 23217713
4. Puigserver, P. et al. (1998) Cell 92, 829-39. PMID: 9529258
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Mouse PPARGC1A Polyclonal Antibody

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