Human STAT3 Recombinant Protein (N-His) (HW708022)

Name: Human STAT3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HW708022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HW708022
Description	Recombinant Human STAT3 Protein, N-His (HW708022) expressed in E. coli, spanning Glu139-Leu483. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P40763
Protein length	Glu139-Leu483
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	42.17 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	APRF, Acute-phase response factor, STAT3, Signal transducer and activator of transcription 3
Background	Signal transducer and activator of transcription 3 is a ~88 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. 1. Tsai, YT. et al. (2000) Molecular and cellular biology 20, 2043-54. PMID: 10688651 2. Yamamoto, T. et al. (2002) Biochemical and biophysical research communications 297, 811-7. PMID: 12359225 3. Shao, H. et al. (2003) Cancer research 63, 3923-30. PMID: 12873986 4. Dreuw, A. et al. (2004) The Journal of biological chemistry 279, 36112-20. PMID: 15194700 5. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 15653507 6. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960 7. Saxena, NK. et al. (2007) The Journal of biological chemistry 282, 13316-25. PMID: 17344214 8. Jiang, H. et al. (2008) Biochemical and biophysical research communications 368, 1-5. PMID: 18242580 9. Hou, T. et al. (2008) The Journal of biological chemistry 283, 30725-34. PMID: 18782771 10. Gao, X. et al. (2012) Molecular cell 45, 598-609. PMID: 22306293
Note	For research use only