Mouse UCP1 Recombinant Protein (N-GST & C-His) (MB024012)

Name: Mouse UCP1 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: MB024012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MB024012
Description	Recombinant Mouse UCP1 Protein, N-GST & C-His (MB024012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P12242
Protein length	Pro33-Lys73&Thr134-Thr178&Val233-Ala266
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Mitochondrial brown fat uncoupling protein 1, Slc25a7, Solute carrier family 25 member 7, Thermogenin, UCP 1, Ucp, Ucp1
Background	Mitochondrial brown fat uncoupling protein 1 is a ~33 kDa protein. Mitochondrial transporter that functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Regulates the production of reactive oxygen species/ROS by mitochondria. 1. Fedorenko, A. et al. (2012) Cell 151, 400-13. PMID: 23063128 2. Feldmann, HM. et al. (2009) Cell metabolism 9, 203-9. PMID: 19187776 3. Chouchani, ET. et al. (2016) Nature 532, 112-6. PMID: 27027295 4. Enerbäck, S. et al. (1997) Nature 387, 90-4. PMID: 9139827 5. Dlasková, A. et al. (2010) Biochimica et biophysica acta 1797, 1470-6. PMID: 20416274 6. Oelkrug, R. et al. (2010) The Journal of biological chemistry 285, 21961-8. PMID: 20466728
Note	For research use only

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Datasheet

Mouse UCP1 Recombinant Protein (N-GST & C-His).pdf

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Mouse UCP1 Recombinant Protein (N-GST & C-His) (MB024012)

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