IFNGR1 (Interferon Gamma Receptor 1, also designated CD119) is the ligand-binding subunit of the IFN-γ receptor complex. Expressed on most nucleated cells, IFNGR1 is essential for IFN-γ-mediated immune activation — driving macrophage activation, MHC class II upregulation, Th1 polarization, and anti-tumor immunity. Deficiency in IFNGR1 causes Mendelian susceptibility to mycobacterial disease (MSMD), underscoring its critical role in host defense.
abinScience provides a complete IFNGR1/CD119 reagent panel — a recombinant antibody (SAA0044) available in multiple fluorochrome conjugates for flow cytometry, a polyclonal antibody for broader applications, and recombinant IFNGR1 proteins in multiple tag formats.
Why abinScience?
✓ Flow cytometry panel — Clone SAA0044 pre-conjugated to FITC, PE, APC, and PerCP for multi-color panels
✓ Recombinant antibody — Defined sequence, lot-to-lot consistency, animal-free production
✓ Human & mouse proteins — Recombinant IFNGR1 with His-tag and Fc-tag options for binding assays and ELISAs
Available Products
Anti-IFNGR1/CD119 Conjugated Antibodies (Flow Cytometry)
Recombinant clone SAA0044 in four fluorochrome conjugates for multi-color flow cytometry panels.
IFNGR1 / CD119 Recombinant Proteins
Purified recombinant IFNGR1 extracellular domain in multiple tag formats for binding studies, ELISA development, and ligand-receptor interaction assays.
About the Target
Gene: IFNGR1 (also: CD119, IFN-gamma-R1)
UniProt: P15260 (Human)
Molecular weight: ~52 kDa (glycosylated extracellular domain)
Receptor complex: IFNGR1 (ligand-binding) + IFNGR2 (signal-transducing)
IFN-γ signaling requires the assembly of a heterotetrameric receptor complex: two IFNGR1 subunits bind IFN-γ, followed by recruitment of two IFNGR2 subunits that activate JAK1 and JAK2. This triggers STAT1 phosphorylation, homodimerization, and nuclear translocation to drive transcription of interferon-stimulated genes (ISGs). IFNGR1 surface expression is dynamically regulated and serves as a biomarker for immune activation status in T cells, NK cells, and macrophages.
Frequently Asked Questions
What is IFNGR1/CD119?
IFNGR1 (CD119) is the ligand-binding chain of the interferon gamma receptor. It binds IFN-γ on the cell surface and, together with IFNGR2, initiates JAK-STAT signaling that drives immune activation, antigen presentation, and anti-microbial responses.
Which conjugate should I use for flow cytometry?
Choose based on your existing panel design. PE and APC provide the brightest signal for low-abundance surface markers. FITC is suitable for abundant markers but has higher autofluorescence. PerCP offers good separation from PE and FITC in multi-color panels. All four conjugates use the same clone (SAA0044) for consistent specificity.
What is the Fc-tagged IFNGR1 protein used for?
Fc-tagged IFNGR1 creates a bivalent form of the receptor extracellular domain, which is useful for IFN-γ binding assays (SPR, BLI), ELISA plate coating (the Fc domain binds Protein A/G for oriented immobilization), and as a blocking reagent to neutralize IFN-γ in cell culture experiments.
Need Help Selecting the Right Product?
Our scientists can help match the right antibody or protein to your application.
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All products are for research use only (RUO). Not intended for diagnostic or therapeutic use. Product availability and specifications are subject to change. Visit individual product pages for the most current information.
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