Systems vaccinology of adjuvanted vaccines reveals early innate signatures predictive of adaptive immunity

Nature

Adjuvants shape the quality and durability of vaccine responses through early innate immune programs. Using multi-omics profiling of human vaccinees, we identify conserved early transcriptional and cellular signatures that predict subsequent adaptive responses across distinct adjuvant platforms, providing a framework for rational adjuvant selection.

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Systems vaccinology of adjuvanted vaccines reveals early innate signatures predictive of adaptive immunity

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