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Epitope-diverse autoantibodies induce neutrophil–epithelial niches driving kidney injury in ANCA-associated glomerulonephritis

Journal of Experimental Medicine

Injured kidney cells send signals that attract immune cells, including neutrophils, which drive the spread of inflammation in the early stages of ANCA-associated glomerulonephritis. Epitope-diverse autoantibodies induce neutrophil–epithelial niches.

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Epitope-diverse autoantibodies induce neutrophil–epithelial niches driving kidney injury in ANCA-associated glomerulonephritis