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Ravulizumab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial (related clinical context)

Nature Medicine

An interim analysis of a phase 3 randomized trial involving adults with IgA nephropathy showed that ravulizumab, a terminal complement inhibitor, led to a significantly greater reduction in proteinuria than placebo.

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HF687016 Anti-Human Complement C5 Reference Antibody (Ravulizumab Ravulizumab (HF687016) is a research-grade recombinant antibody targeting CPAMD4. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns. CPAMD4, C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5