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PD-L1 expression in germinal centers promotes humoral immunity by restricting T follicular regulatory cell differentiation

Immunity

Germinal center (GC) responses generate humoral immunity through coordinated interactions between B cells and T follicular helper (TFH) and T follicular regulatory (TFR) cells. Despite high expression of PD-1 by TFH and TFR cells, the function of its ligand PD-L1 in the GC is unclear. PD-L1 expression on stromal cells enhances T-B cell collaborations and humoral immunity.

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Catalog No.	Product Name	Description	Target
HV974336	Anti-Human PD-L1 Reference Antibody (NM-01	Anti-Human CD274/PD-L1/B7-H1 (NM-01) (HV974336) is a research-grade recombinant antibody targeting CD1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.	B7 homolog 1, B7-H1, B7H1, CD274, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1

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PD-L1 expression in germinal centers promotes humoral immunity by restricting T follicular regulatory cell differentiation