Autophagy in macrophages curtails IL-1α-mediated immune priming against lung infections

Nature Immunology

Host resistance to infection is initially determined by how well primed the innate immune system is to respond on first exposure to an invader. Basal autophagy suppressed the expression of Il1a in alveolar macrophages (AMs) and an otherwise protective innate immune priming against Staphylococcus aureus and other respiratory pathogens.

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Autophagy in macrophages curtails IL-1α-mediated immune priming against lung infections