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Nuclear NAD+ inhibits the histone demethylase KMD5A to promote trained immunity

Science Immunology

Nuclear NAD+ licenses trained immunity by directly restraining the H3K4me3 eraser KDM5a. NAD+ is revealed to be a metabolic signal that preserves an epigenetic mark central to trained immunity.

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Nuclear NAD+ inhibits the histone demethylase KMD5A to promote trained immunity