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Lonidamine ameliorates MASH by reducing SREBP1 and inhibiting the MAPK pathway

Yuhan Chen, Feiyan Pan, Lusheng Tang, et al. Lonidamine ameliorates MASH by reducing SREBP1 and inhibiting the MAPK pathway [J]. Acta Biochimica et Biophysica Sinica, 2026-03-05. 2026-04-17. https://www.sciengine.com/doi/10.3724/abbs.2026033.

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Dysregulated Klotho and FGF23 signaling aggravates vascular remodeling in age-related pulmonary hypertension

Paul-Lennard Perret, Jonathan H Kim, Annika Winkler, Christiane Ott, Willem Bintig, Teresa C Funk-Hilsdorf, Erik Asmus, Szandor Simmons, Laura Michalick, Philip D Solymosi, Petra Knaus, Catrin Herpich, Kristina Norman, Ursula Müller-Werdan, Vasile Foris, Gabor Kovacs, Makoto Kuro-O, Tilman Grune, Jakob Voelkl, Jana Grune, Wolfgang M Kuebler, Dysregulated Klotho and FGF23 signaling aggravates vascular remodeling in age-related pulmonary hypertension, Cardiovascular Research, 2026;, cvag048

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A Covalent Targeted Platform for Protein Dynamic Tracking

Chen B, Cheng Y, Men Z, Zhang W, Hu JJ, Xia F, Lou X. A Covalent Targeted Platform for Protein Dynamic Tracking. Anal Chem. 2026 Mar 10;98(9):7136-7146. doi: 10.1021/acs.analchem.6c00347. Epub 2026 Feb 22. PMID: 41725287.

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HSPA1A and DNAJB1 regulate NELF condensate dynamics to safeguard transcriptional recovery under heat stress

Jiang S, Jia Z, Zhu W, Liu Y, Fu H, Zhu F, Li Z, Yang J, Zhu Y, Sun Z, Zhu T, Quan X, Jiao H, Huang K, Wu Z, Zou W, Yang B, Lu Y, Zhang L, Zhou F, Fang D, Lu H. HSPA1A and DNAJB1 regulate NELF condensate dynamics to safeguard transcriptional recovery under heat stress. Mol Cell. 2026 Feb 19;86(4):674-692.e10. doi: 10.1016/j.molcel.2026.01.015. Epub 2026 Feb 6. PMID: 41653920.

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Monoclonal IgM antibodies mediate potent complement neutralization by targeting cell-derived epitopes on enveloped viruses

Kainulainen MH, Harmon JR, Bergeron É, Davies KA, LeBlanc ML, Clines C, Bentz ML, Montgomery JM, Spiropoulou CF.0.Monoclonal IgM antibodies mediate potent complement neutralization by targeting cell-derived epitopes on enveloped viruses. mBio0:e01709-25.https://doi.org/10.1128/mbio.01709-25IF: 4.7 Q1

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Artesunate ameliorates experimental autoimmune uveitis by inhibiting the LCN2-STAT3 axis and suppressing microglial activation

Gu, J., Xia, Q., Huang, P., Yuan, Y., Ren, H., Hua, D., & Chen, Z. (2026). Artesunate ameliorates experimental autoimmune uveitis by inhibiting the LCN2-STAT3 axis and suppressing microglial activation. Redox Report, 31(1). https://doi.org/10.1080/13510002.2026.2627096IF: 7.4 Q1

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Tumor-derived S100A14 targeted astrocytes via TLR4 to Recruit myeloid-derived suppressor cells promoting brain metastasis and Curdione reversal effect

Feng Q, Wang XY, Yang X, Liu GC, Xie CJ, Cai ZH, Wang MR, Zhang R, Liu ZQ, Zhang RR. Tumor-derived S100A14 targeted astrocytes via TLR4 to Recruit myeloid-derived suppressor cells promoting brain metastasis and Curdione reversal effect. Phytomedicine. 2026 Apr;153:157965. doi: 10.1016/j.phymed.2026.157965. Epub 2026 Feb 11. PMID: 41691987.

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FungiGuard: identification of plant antifungal peptides with artificial intelligence

Li X, Fang Y, Wu Y, Yu X. FungiGuard: identification of plant antifungal peptides with artificial intelligence. Genome Biol. 2026 Feb 6. doi: 10.1186/s13059-026-03983-6. Epub ahead of print. PMID: 41645295.

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Migraine-induced cochlear injury triggers ZBP1-mediated PANoptosis via CGRP signaling

Xu, W., Zhai, N., Chen, J. et al. Migraine-induced cochlear injury triggers ZBP1-mediated PANoptosis via CGRP signaling. J Headache Pain 27, 61 (2026).

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A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis

Yan W, Talley DC, Syam A, Danchik C, Zhong Y, Zhang X, Liu X, Baljinnyam B, Kales SC, Cyr MG, Fang Y, Zakharov AV, Hu X, Niehoff T, Xu T, Qu Y, Yang A, Courouble VV, Yao Q, Simeonov A, Huang R, Rostovtseva TK, Bezrukov SM, LeClair CA, Egan JM, Wang H, Tao D, Rai G, Henderson MJ, Fang S. A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis. Nat Commun. 2026 Jan 17;17(1):1058. doi: 10.1038/s41467-025-67816-z. PMID: 41547848; PMCID: PMC12847789.

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