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Anti-Human CD163 Antibody (M130), APC (HV831137)

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Número de catálogo	HV831137
Descripción	Anti-Human CD163 Antibody (M130), APC [M130] (HV831137) is a mouse monoclonal antibody detecting CD163 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Mouse
Isotipo	IgG1, kappa
ID de clon	M130
Conjugación	APC
Clonalidad	Monoclonal
Objetivo	Scavenger receptor cysteine-rich type 1 protein M130, M130, Hemoglobin scavenger receptor, CD163, sCD163
Nivel de endotoxinas	Please contact with the lab for this information.
Número de acceso	Q86VB7
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Scavenger receptor cysteine-rich type 1 protein M130 (CD163) is a ~125 kDa protein. Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Referencias

Neuroinflammation in Obese Children

Datasheet

Anti-Human CD163 Antibody (M130), APC.pdf

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Anti-Human CD163 Antibody (M130), APC