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Anti-Human CD14 Antibody (F1024D), PerCP (HY038247)

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개요

카탈로그 번호	HY038247
설명	Anti-Human CD14 Antibody (F1024D), PerCP [F1024D] (HY038247) is a human monoclonal antibody detecting CD14 in ELISA, FCM, WB. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
종 반응성	Human
응용 분야	ELISA, FCM, WB
숙주 종	Human
이소타입	IgG1
클론 ID	F1024D
접합	PerCP
클론성	Monoclonal
타겟	Myeloid cell-specific leucine-rich glycoprotein, CD14, Monocyte differentiation antigen CD14, RHC33701
내독소 수준	Please contact with the lab for this information.
등록번호	P08571
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	Monocyte differentiation antigen CD14 is a ~40 kDa protein. Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). 1. Wright, SD. et al. (1990) Science (New York, N.Y.) 249, 1431-3. PMID: 1698311 2. Kelley, SL. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1304-11. PMID: 23264655 3. Tsukamoto, H. et al. (2010) International immunology 22, 271-80. PMID: 20133493 4. Murakami, K. et al. (2012) FEBS letters 586, 319-24. PMID: 22265692 5. Haziot, A. et al. (1996) Immunity 4, 407-14. PMID: 8612135 6. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 16880211 7. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD14 Antibody (F1024D), PerCP.pdf

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Anti-Human CD14 Antibody (F1024D), PerCP