Anti-Human ErbB2/Her2 Reference Antibody (Trastuzumab, RUO) (HY286016)

Name: Anti-Human ErbB2/Her2 Reference Antibody (Trastuzumab, RUO)
Brand: abinScience
SKU: HY286016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HY286016
Description	Trastuzumab (HY286016) is a research-grade recombinant antibody targeting CD340. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	p185erbB2, HER2, NGL, Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P04626
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	timigutuzumab, 4D5-8, 4D5V8, Herceptin, rhuMabHER2, 180288-69-1
Background	Receptor tyrosine-protein kinase erbB-2 (CD340/ERBB2) is a ~137 kDa protein. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. CD340 is the therapeutic target of trastuzumab (Herceptin) and trastuzumab deruxtecan (Enhertu).
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects Human ERBB2 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Trastuzumab.
HPLC

SEC-HPLC detection for Research Grade Trastuzumab.

References

Chemical coupling of biological magnetosomes with amine-functionalized therapeutic antibody conjugates

Datasheet

Anti-Human ErbB2/Her2 Reference Antibody (Trastuzumab, RUO).pdf

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Recombinant Proteins

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Anti-Human ErbB2/Her2 Reference Antibody (Trastuzumab, RUO) (HY286016)

Overview

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References

Datasheet

SDS

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