All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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CD268/TNFRSF13C (2)

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shiga toxin type 1B/stx1B (2)

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Varicella-zoster virus (VZV/HHV-3) (4)

Mouse (33)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

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Dengue virus type 1 (DENV-1) (1)

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Human endogenous retroviruses W (HERV-W) (1)

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E. coli (4)

Human papillomavirus 6 (HPV6) (1)

Japanese encephalitis virus (JEV) (1)

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Human parvovirus B19 (HPV B19) (3)

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Clostridium botulinum (2)

Campylobacter jejuni subsp. (1)

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in vivo research (1)

IF (20)

RIA (1)

IB (1)

IHC (18)

Cell Isolation (1)

IP (9)

in vivo neutralization (5)

in vivo protection (1)

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neutralizing (1)

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in vivo neutrophil depletion (2)

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NK cell activation (1)

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SPR (46)

in vivo study (1)

ICC (3)

BLI (4)

in vivo intra-tumoral regulatory T cell depletion (2)

Neutralizatio (1)

in vivo (2)
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Japanese encephalitis virus (JEV) (2)

RD114 retrovirus (1)

Dengue Virus type 4 (DENV-4) (1)

Mexican scorpion (3)

Parainfluenza virus 5 (PIV5) (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Human (57)

Influenza A virus (H7N9) (1)

HIV-1 (1)

IgG1b12 (1)

Venezuelan equine encephalitis virus (VEEV) (1)

Human metapneumovirus (HMPV) (1)

E. coli (1)

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Junin mammarenavirus (JUNV) (3)

Measles virus (MeV) (2)

Sin Nombre Virus (1)

Chikungunya virus (CHIKV) (4)

Human papillomavirus 16 (HPV16) (13)

MERS-CoV (2)

Western equine encephalitis virus (WEEV) (1)

Human cytomegalovirus (HCMV/HHV-5) (1)

Foot-and-mouth disease virus (FMDV) (2)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Zika virus (ZIKV) (1)

Coxsackievirus B1 (CVB1) (3)

Machupo virus (MACV) (1)

Puumala virus (1)

Bacillus anthracis (2)

Mayaro virus(MAYV) (1)

Monkeypox virus (5)

Escherichia coli (1)

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Ophiophagus hannah (1)

Clostridium perfringens (3)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Poliovirus type 1 (PV1) (1)

West Nile virus (WNV) (1)

Bacteriophage H19B (2)

Guertu Virus (GTV) (3)

Lassa virus (LASV) (16)

Dengue virus (1)

Human respiratory syncytial virus (HRSV) (5)

HCoV-229E (2)

Canine parvovirus (1)

Hendra virus (HeV) (12)

Hepatitis C Virus (HCV) (43)

Ross River Virus (RRV) (2)

Murine norovirus 1 (MNV) (1)

Influenza A virus (1)

Klebsiella pneumoniae (1)

O’nyong’nyong virus (ONNV) (1)

Vaccinia virus (VACV) (20)

Coxsackievirus A16 (CVA16) (3)

Heartland Virus (HRTV) (1)

Mouse (25)

HAstV-1 (2)

Zika virus (1)

HCoV-OC43 (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Hepatitis E virus/HEV (3)

Pig (1)

Nipah virus (NiV) (13)

O'nyong'nyong virus (ONNV) (1)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Chikungunya virus (1)

Theileria parva (1)

Clostridium botulinum (1)

Dengue Virus type 1 (DENV-1) (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Monkey (1)

Human enterovirus 71 (EV71) (3)

Influenza A virus (H7N1) (1)

Clostridium tetani (1)

SARS-CoV (1)

Naja kaouthia (1)

HCoV-NL63 (1)

Clostridioides difficile (2)

Semliki Forest virus (SFV) (1)

Norwalk virus (NV) (5)

Tick-borne encephalitis virus (1)

Porcine circovirus 2 (PCV2) (1)

Monkeypox virus (MPXV) (12)

Human astrovirus-8 (HAtVs) (1)

Dengue Virus type 2 (DENV-2) (1)

Staphylococcus aureus (3)

Streptococcus equisimilis (1)

Scorpion (2)

Bovine viral diarrhea virus (BVDV) (2)

Vesicular stomatitis Indiana virus (VSIV) (2)

Influenza A virus (H7N3) (2)

SARS-CoV-2 (1)

HSV-1 (3)

Rat (5)

Hepatitis E virus (2)

Hendra virus (1)

Corynephage omega (3)

Human coronavirus HKU1 (HCoV-HKU1) (1)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Human astrovirus-2 (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Homo sapiens (Human) (1)

Dengue Virus type 3 (DENV-3) (1)

Rabies virus (RABV) (6)

HSV-2 (3)

Crimean-Congo hemorrhagic fever virus (2)

Listeria monocytogenes (1)

Nipah virus (1)

Norwalk virus (3)

Influenza B virus (2)

Influenza A virus H7 subtype (2)
Host species

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Cat (1)

Dog (8)

Human (463)

Rabbit (2)

Rat (10)

Alpaca (23)

Mouse (215)
Clonality

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Monoclonal (727)
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Unconjugated (727)