All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

Home > Products > Antibodies > Neutralizing Antibodies

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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Human parvovirus B19 (HPV B19) (3)

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Rotavirus (RV) (1)

Human immunodeficiency virus 1 (HIV-1) (9)

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Dengue virus type 3 (DENV-3) (1)

Coxsackievirus A16 (CVA16) (2)

Human papillomavirus 59 (HPV59) (1)
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SPR (46)

Nneutralization (1)

Cell Isolation (1)

in vivo neutralization (5)

IP (9)

in vivo neutrophil depletion (2)

neutralizing (1)

in vivo study (1)

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ICC (3)

in vivo (2)

Blocking (2)

IF (20)

IHC (18)
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Hendra virus (1)

Chikungunya virus (1)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Escherichia coli (1)

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Rabies virus (RABV) (6)

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Human enterovirus 71 (EV71) (3)

Norwalk virus (NV) (5)

Canine parvovirus (1)

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Klebsiella pneumoniae (1)

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Mouse (25)

Human papillomavirus 16 (HPV16) (13)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Venezuelan equine encephalitis virus (VEEV) (1)

Theileria parva (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Heartland Virus (HRTV) (1)

HAstV-1 (2)

Porcine circovirus 2 (PCV2) (1)

Clostridium tetani (1)

Homo sapiens (Human) (1)

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Monkey (1)

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Influenza A virus (H7N1) (1)

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Human cytomegalovirus (HCMV/HHV-5) (1)

Mexican scorpion (3)

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Hendra virus (HeV) (12)

Hepatitis E virus (2)

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Ross River Virus (RRV) (2)

Monkeypox virus (5)

Rat (5)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Human astrovirus-2 (1)

Human astrovirus-8 (HAtVs) (1)

Eastern equine encephalitis virus (EEEV) (1)

Dengue Virus type 2 (DENV-2) (1)

Ophiophagus hannah (1)

Lassa virus (LASV) (16)

Machupo virus (MACV) (1)

Dengue virus (1)

Influenza A virus (H7N3) (2)

Human respiratory syncytial virus (HRSV) (5)

SARS-CoV-2 (1)

Listeria monocytogenes (1)

Coxsackievirus A16 (CVA16) (3)

Vaccinia virus (VACV) (20)

HCoV-229E (2)

HSV-2 (3)

Nipah virus (NiV) (13)

O'nyong'nyong virus (ONNV) (1)

Norwalk virus (3)

RD114 retrovirus (1)

Influenza A virus H7 subtype (2)

O’nyong’nyong virus (ONNV) (1)

Dengue Virus type 3 (DENV-3) (1)

Zika virus (1)

Human metapneumovirus (HMPV) (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Influenza A virus (H7N9) (1)

HCoV-OC43 (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Human (57)

Japanese encephalitis virus (JEV) (2)

Semliki Forest virus (SFV) (1)

HIV-1 (1)

IgG1b12 (1)

E. coli (1)

Puumala virus (1)

Dengue Virus type 4 (DENV-4) (1)

Monkeypox virus (MPXV) (12)

Bacteriophage H19B (2)

Clostridium perfringens (3)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Bovine viral diarrhea virus (BVDV) (2)

Murine norovirus 1 (MNV) (1)

Sin Nombre Virus (1)

HCoV-NL63 (1)

Corynephage omega (3)

MERS-CoV (2)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Vesicular stomatitis Indiana virus (VSIV) (2)

Yellow Fever Virus (YFV) (1)

Measles virus (MeV) (2)

Naja kaouthia (1)

Bacillus anthracis (2)
Host species

0 selected

Rat (10)

Mouse (215)

Cat (1)

Alpaca (23)

Dog (8)

Rabbit (2)

Human (463)
Clonality

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Monoclonal (727)
Conjugate

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Unconjugated (727)