All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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CCL14/NCC-2 (1)

PA/pagA/PA-83 (2)

gp120 (2)

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HSV- gB (1)

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gp120/Glycoprotein 120 (1)

RSPO3 (1)

GDF15/MIC1 (1)

CD120b/TNFR2 (1)

shiga toxin type 2A/stx2A (1)

ProteinUL128 & UL131A (1)
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Human respiratory syncytial virus (HRSV) (12)

Campylobacter jejuni subsp. (1)

Human parvovirus B19 (HPV B19) (3)

Bovine respiratory syncytial virus (BRSV) (2)

Reston ebolavirus (REBOV) (1)

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Human herpesvirus 1 (HSV-1/HHV-1) (3)

Bundibugyo ebolavirus (BDBV) (1)

Human metapneumovirus (2)

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Dog (10)

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Cat (1)

Streptococcus pneumoniae (1)

Tai Forest ebolavirus (TAFV) (1)

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Brazilian scorpion (1)

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Monkey (1)

Human hepatitis A virus (HHAV) (1)

Human papillomavirus 59 (HPV59) (1)

Puumala virus (PUUV) (2)

Japanese encephalitis virus (JEV) (1)

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Junin mammarenavirus (JUNV) (1)

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Varicella-zoster virus (VZV/HHV-3) (4)

Mouse (33)

Dobrava-Belgrade virus (DOBV) (2)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Poliovirus type 1 (PV1) (2)

Dengue virus type 2 (DENV-2) (8)

Dengue virus type 3 (DENV-3) (1)

Seoul virus (SEOV) (2)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

Human papillomavirus 58 (HPV58) (3)

Human astrovirus-8 (HAtVs) (1)

Staphylococcus aureus (3)

Epstein-Barr virus (EBV/HHV-4) (2)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

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Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

Lassa virus (LASV) (1)

Dengue virus type 4 (DENV-4) (1)

Hendra virus (HeV) (2)

Andes virus (ANDV) (2)

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Nipah virus (NiV) (13)

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Human (177)

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Human adenovirus 3 (HAdV-3) (1)

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Human endogenous retroviruses W (HERV-W) (1)

Plasmodium vivax (2)

Coxsackievirus B1 (CBV1) (3)

Zaire ebolavirus (ZEBOV) (6)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Rat (1)

E. coli (4)
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DB (3)

Nneutralization (1)

Cell Isolation (1)

IP (9)

in vivo neutralization (5)

in vivo neutrophil depletion (2)

in vivo study (1)

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Neutralizatio (1)

Neutralization (706)

RIA (1)

in vivo protection (1)

IB (1)

neutralizing (1)

in vivo research (1)

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in vitro neutralization (1)

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Western blot (1)

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in vivo CTLA-4 neutralization (2)

FuncS (4)

NK cell activation (1)

in vivo intra-tumoral regulatory T cell depletion (2)

ICC (3)

BLI (4)

in vivo (2)

Blocking (2)

Antagonist (1)

IF (22)

IHC (18)
Reactivity

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Hepatitis C Virus (HCV) (43)

Ross River Virus (RRV) (2)

MERS-CoV (2)

Homo sapiens (Human) (1)

Japanese encephalitis virus (JEV) (2)

Measles virus (MeV) (2)

Lassa virus (LASV) (16)

Sin Nombre Virus (1)

Dengue virus (1)

Human respiratory syncytial virus (HRSV) (5)

Dengue Virus type 4 (DENV-4) (1)

Hendra virus (HeV) (12)

Hendra virus (1)

Coxsackievirus A16 (CVA16) (3)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Vaccinia virus (VACV) (20)

Nipah virus (NiV) (13)

O'nyong'nyong virus (ONNV) (1)

Escherichia coli (1)

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Pig (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Crimean-Congo hemorrhagic fever virus (2)

Nipah virus (1)

Influenza B virus (2)

Influenza A virus (1)

Semliki Forest virus (SFV) (1)

Klebsiella pneumoniae (1)

Porcine circovirus 2 (PCV2) (1)

Guertu Virus (GTV) (3)

Clostridium tetani (1)

Canine parvovirus (1)

Zika virus (ZIKV) (1)

Clostridioides difficile (2)

Mouse (25)

Bovine viral diarrhea virus (BVDV) (2)

Venezuelan equine encephalitis virus (VEEV) (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Monkeypox virus (MPXV) (12)

Corynephage omega (3)

Theileria parva (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Heartland Virus (HRTV) (1)

Poliovirus type 1 (PV1) (1)

HAstV-1 (2)

Vesicular stomatitis Indiana virus (VSIV) (2)

Hepatitis E virus/HEV (3)

West Nile virus (WNV) (1)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Puumala virus (1)

Western equine encephalitis virus (WEEV) (1)

Junin mammarenavirus (JUNV) (3)

Tick-borne encephalitis virus (1)

Bacteriophage H19B (2)

Clostridium perfringens (3)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Influenza A virus (H7N1) (1)

SARS-CoV (1)

Rabies virus (RABV) (6)

Listeria monocytogenes (1)

Parainfluenza virus 5 (PIV5) (1)

Monkeypox virus (5)

Rat (5)

Eastern equine encephalitis virus (EEEV) (1)

Ophiophagus hannah (1)

RD114 retrovirus (1)

Machupo virus (MACV) (1)

Murine norovirus 1 (MNV) (1)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Monkey (1)

Human astrovirus-2 (1)

Human metapneumovirus (HMPV) (1)

Clostridium botulinum (1)

Influenza A virus (H7N3) (2)

Dengue Virus type 1 (DENV-1) (1)

SARS-CoV-2 (1)

HSV-1 (3)

Hepatitis E virus (2)

HCoV-229E (2)

Chikungunya virus (1)

Human cytomegalovirus (HCMV/HHV-5) (1)

O’nyong’nyong virus (ONNV) (1)

Human papillomavirus 16 (HPV16) (13)

Human enterovirus 71 (EV71) (3)

Influenza A virus H7 subtype (2)

Human astrovirus-8 (HAtVs) (1)

Dengue Virus type 2 (DENV-2) (1)

HSV-2 (3)

Norwalk virus (3)

Chikungunya virus (CHIKV) (4)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

HCoV-OC43 (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Human (57)

Coxsackievirus B1 (CVB1) (3)

Foot-and-mouth disease virus (FMDV) (2)

Norwalk virus (NV) (5)

Bacillus anthracis (2)

HIV-1 (1)

Mayaro virus(MAYV) (1)

IgG1b12 (1)

Scorpion (2)

E. coli (1)

Influenza A virus (H7N9) (1)

Dengue Virus type 3 (DENV-3) (1)

Staphylococcus aureus (3)

Streptococcus equisimilis (1)

Naja kaouthia (1)

HCoV-NL63 (1)
Host species

0 selected

Dog (8)

Cat (1)

Rat (10)

Alpaca (23)

Mouse (215)

Rabbit (2)

Human (463)
Clonality

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Monoclonal (727)
Conjugate

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Unconjugated (727)