All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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LAMP5 (2)

IFNB1/IFN-beta (1)

Envelope glycoprotein GP350 (1)

gp125 (1)

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mature virion in complex (5)

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long-chain neurotoxin (1)

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Mature virion in Complex [(VP0/1/3)5]12 (2)

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shiga toxin type 2A/stx2A (1)

BAG3 (1)

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gp46 (2)

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botA/BoNT (2)

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Neuropeptide Y/NPY (1)

LRRC15/LIB (1)

CD84 (1)

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C1S (1)

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ERVW-1/HERV-W-Env (1)

S1 N-terminal domain/S1-NTD (3)

IGF1 (1)

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E1 & E2 (gp35 & gp70) (3)

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A35R (5)

shiga toxin type 2/stx2B (1)

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wlaB/pglK (1)

ADAMTS5 (2)

IL13 (1)

GPRC5D (1)

CD319/SLAMF7 (1)

CDH1/CDH11 (1)

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SERPINE1/PAI-1 (1)

gp32/gp35/Envelope glycoprotein E1 (1)

ARG1/Arginase-1 (2)

ROBO4 (1)

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MERS-CoV RBD (1)

Protein prM/prM (3)

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GPC (18)

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IGF2 (1)

ANGPTL3 (1)

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PSCA (1)

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CD100/SEMA4D (3)

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SOD1 (1)

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APCS/PTX2 (1)

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G/Major surface glycoprotein G (2)

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CLDN3/Claudin-3 (1)

IL31RA (1)

H3L/Ag35 (2)

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L1/Major capsid protein L1 (2)

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IL23A (1)

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shiga toxin type 1B/stx1B (2)

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Procapsid [(VP0/1/3) 5] 12 (2)

aPC/Activated protein C (3)

PDGFD (1)

Capsid (1)

IL2 (1)

CCL24/Eotaxin-2/MPIF-2 (1)

pro-MSTN/GDF8 (1)

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Pre-F/Fusion glycoprotein F0 (2)

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Hemagglutinin (1)

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fimH (1)

IL5 (1)

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IL20 (1)

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IL1B/IL1F2 (1)

CD52 (1)
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Human papillomavirus 59 (HPV59) (1)

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Sudan ebolavirus (SEBOV) (1)

Monkey (1)

Human hepatitis A virus (HHAV) (1)

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Junin mammarenavirus (JUNV) (1)

Mouse (33)

Staphylococcus aureus (3)

Dobrava-Belgrade virus (DOBV) (2)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

Orthohantavirus puumalaense (PUUV) (1)

Varicella-zoster virus (VZV/HHV-3) (4)

Epstein-Barr virus (EBV/HHV-4) (2)

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Seoul virus (SEOV) (2)

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Hendra virus (HeV) (2)

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Hepatitis C Virus (HCV) (9)

Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

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Dengue virus type 4 (DENV-4) (1)

Human (177)

Andes virus (ANDV) (2)

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Nipah virus (NiV) (13)

Plasmodium vivax (2)

Human papillomavirus 16 (HPV16) (2)

Rotavirus (RV) (1)

Coxsackievirus B1 (CBV1) (3)

Human immunodeficiency virus 1 (HIV-1) (9)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Zika virus (ZIKV) (4)

Human respiratory syncytial virus (HRSV) (12)

Clostridium botulinum (2)

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Rat (1)

E. coli (4)

Rotavirus A (RV-A) (3)

Human adenovirus 3 (HAdV-3) (1)

Sin Nombre virus (SNV) (2)

Human endogenous retroviruses W (HERV-W) (1)

Zaire ebolavirus (ZEBOV) (6)

Campylobacter jejuni subsp. (1)

Human parvovirus B19 (HPV B19) (3)

Bovine respiratory syncytial virus (BRSV) (2)

Reston ebolavirus (REBOV) (1)

Human papillomavirus 6 (HPV6) (1)

Clostridioides difficile (2)

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Dog (10)

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Porcine circovirus 2 (PCV2) (2)

Hantaan virus (HTNV) (2)

Ebola virus (EBOV) (1)

Coxsackievirus A16 (CVA16) (2)

Cat (1)

Streptococcus pneumoniae (1)

Tai Forest ebolavirus (TAFV) (1)
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WB (59)

FCM (120)

SPR (46)

Western blot (1)

in vivo CTLA-4 neutralization (2)

FuncS (4)

NK cell activation (1)

ICC (3)

in vivo intra-tumoral regulatory T cell depletion (2)

BLI (4)

in vivo (2)

Blocking (2)

Antagonist (1)

IF (20)

IHC (18)

DB (3)

IP (9)

Nneutralization (1)

Cell Isolation (1)

in vivo neutralization (5)

Neutralizatio (1)

Neutralization (706)

in vivo neutrophil depletion (2)

in vivo study (1)

Cell Depletion (1)

neutralizing (1)

RIA (1)

in vivo protection (1)

IB (1)

in vivo research (1)

in vivo MDSC depletion (2)

ELISA (621)

in vitro neutralization (1)

in vivo CD8+ T cell depletion (1)
Reactivity

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RD114 retrovirus (1)

Junin mammarenavirus (JUNV) (3)

Puumala virus (1)

Western equine encephalitis virus (WEEV) (1)

Rabies virus (RABV) (6)

Listeria monocytogenes (1)

Tick-borne encephalitis virus (1)

Bacteriophage H19B (2)

Human metapneumovirus (HMPV) (1)

Clostridium perfringens (3)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Influenza A virus (H7N1) (1)

SARS-CoV (1)

Ophiophagus hannah (1)

Machupo virus (MACV) (1)

Murine norovirus 1 (MNV) (1)

Parainfluenza virus 5 (PIV5) (1)

Monkeypox virus (5)

Rat (5)

Eastern equine encephalitis virus (EEEV) (1)

HSV-1 (3)

Hepatitis E virus (2)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Monkey (1)

Human astrovirus-2 (1)

Clostridium botulinum (1)

Influenza A virus (H7N3) (2)

Dengue Virus type 1 (DENV-1) (1)

SARS-CoV-2 (1)

O’nyong’nyong virus (ONNV) (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

HCoV-229E (2)

Chikungunya virus (1)

Human cytomegalovirus (HCMV/HHV-5) (1)

Coxsackievirus B1 (CVB1) (3)

Dengue Virus type 2 (DENV-2) (1)

HSV-2 (3)

Bacillus anthracis (2)

Norwalk virus (3)

Chikungunya virus (CHIKV) (4)

Human papillomavirus 16 (HPV16) (13)

Human enterovirus 71 (EV71) (3)

Influenza A virus H7 subtype (2)

Human astrovirus-8 (HAtVs) (1)

Norwalk virus (NV) (5)

HCoV-OC43 (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Human (57)

Foot-and-mouth disease virus (FMDV) (2)

Influenza A virus (H7N9) (1)

Dengue Virus type 3 (DENV-3) (1)

Staphylococcus aureus (3)

Streptococcus equisimilis (1)

HIV-1 (1)

Mayaro virus(MAYV) (1)

IgG1b12 (1)

Scorpion (2)

E. coli (1)

Naja kaouthia (1)

HCoV-NL63 (1)

Sin Nombre Virus (1)

Dengue virus (1)

Human respiratory syncytial virus (HRSV) (5)

Dengue Virus type 4 (DENV-4) (1)

Pig (1)

Hendra virus (HeV) (12)

Hepatitis C Virus (HCV) (43)

Ross River Virus (RRV) (2)

MERS-CoV (2)

Homo sapiens (Human) (1)

Japanese encephalitis virus (JEV) (2)

Measles virus (MeV) (2)

Lassa virus (LASV) (16)

Hendra virus (1)

Coxsackievirus A16 (CVA16) (3)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Vaccinia virus (VACV) (20)

Zika virus (1)

Yellow Fever Virus (YFV) (1)

Mexican scorpion (3)

Clostridioides difficile (2)

Nipah virus (NiV) (13)

O'nyong'nyong virus (ONNV) (1)

Escherichia coli (1)

Porcine circovirus 2 (PCV2) (1)

Clostridium tetani (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Crimean-Congo hemorrhagic fever virus (2)

Nipah virus (1)

Influenza B virus (2)

Canine parvovirus (1)

Zika virus (ZIKV) (1)

Influenza A virus (1)

Semliki Forest virus (SFV) (1)

Klebsiella pneumoniae (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Guertu Virus (GTV) (3)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Monkeypox virus (MPXV) (12)

Mouse (25)

Bovine viral diarrhea virus (BVDV) (2)

Venezuelan equine encephalitis virus (VEEV) (1)

Hepatitis E virus/HEV (3)

West Nile virus (WNV) (1)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Corynephage omega (3)

Theileria parva (1)

Heartland Virus (HRTV) (1)

Poliovirus type 1 (PV1) (1)

HAstV-1 (2)

Vesicular stomatitis Indiana virus (VSIV) (2)
Host species

0 selected

Mouse (215)

Rabbit (2)

Human (463)

Alpaca (23)

Dog (8)

Cat (1)

Rat (10)
Clonality

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Monoclonal (727)
Conjugate

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Unconjugated (727)