Immune Checkpoint Proteins | Recombinant Proteins

Access 900+ recombinant immune checkpoint proteins spanning established targets (PD-1, PD-L1, CTLA-4, CD80, CD86) and next-generation candidates (LAG-3, TIM-3, TIGIT, VISTA, B7-H3, CD47/SIRPα). Produced in HEK293 and CHO systems for native glycosylation and correct folding. Available as Fc-chimera, His-tagged, and biotinylated formats for binding assays, blocking studies, and CAR-T antigen screening. All products are designated Research Use Only (RUO) — not intended for diagnostic or therapeutic procedures. RUO

Why Researchers Choose abinScience

Complete Checkpoint Panel Co-inhibitory (PD-1, PD-L1, CTLA-4, LAG-3, TIM-3, TIGIT, VISTA) and co-stimulatory (OX40, 4-1BB, ICOS, CD28, GITR) targets in one catalog — build checkpoint panels for multiplex screening.

Fc-Chimera for Avidity & Half-Life Fc-tagged formats enable enhanced binding avidity, Protein A/G purification, and extended half-life in functional assays — ideal for receptor-ligand interaction studies.

CAR-T & Immunotherapy Support Recombinant antigens for CAR construct screening, T-cell activation studies, and bispecific antibody development. Low endotoxin (≤0.1 EU/µg) for cell-based functional assays.

Variant & Mutant Panels Wild-type and mutant variants for key targets — supporting structure-activity relationship (SAR) studies and epitope mapping for therapeutic antibody development.