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In Vivo Antibodies

abinScience in vivo antibodies are functional-grade reagents optimized for animal studies—azide-free, low endotoxin, sterile-filtered and aggregation-tested. Available in blocking, depleting, and neutralizing formats with lot-specific CoA reporting purity, endotoxin (LAL), and sterility. Includes IgG, F(ab')2, and Fc-engineered options. RUO

Why Researchers Choose abinScience

Animal-Compatible Azide-free, carrier-free, sterile buffer
Low Endotoxin LAL-tested, ≤0.1 EU/μg typical
Aggregation Control SEC-HPLC/DLS verified
Flexible Formats IgG, F(ab')2, Fc variants
Lot-Specific QC CoA with endotoxin, purity, sterility

Shop by Function

Shop by Application

Selection & Handling Guide

  1. Function: Select blocking, depleting, or neutralizing based on target and desired MoA.
  2. Format: Choose IgG for Fc-mediated effects (ADCC/CDC); F(ab')2 to eliminate FcγR binding.
  3. Dosing: Follow mg/kg guidelines from literature; common routes: i.p., i.v., s.c.
  4. QC Review: Check lot CoA for endotoxin, purity, and sterility before use.
  5. Controls: Always include matched isotype and vehicle controls.

Applications

Immunotherapy mechanism studies
Cell depletion in vivo
Cytokine blockade in disease models
Vaccine efficacy and immune modulation

Documents & QC

Lot-specific CoA: concentration, endotoxin, purity, sterility
Aggregation data (SEC-HPLC/DLS)
Recommended dosing and handling protocols

FAQs

How is an in vivo antibody different from standard lab grade?

In vivo products are azide-free, low endotoxin, sterile-filtered and aggregation-controlled, with carrier-free buffers and lot-level QC tailored to animal studies.

Should I choose IgG or F(ab')2?

Use IgG for Fc effector functions (depletion/engagement); use F(ab')2 when avoiding FcγR interactions is important.

Recommended endotoxin level?

Select low-endotoxin lots per protocol and record values from the lot-specific CoA; control endotoxin alongside dose and route.

Can these be used in humans?

No. All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic use.

What is InVivo Plus?

InVivo Plus is abinScience’s premium functional-grade specification with defined buffer, endotoxin and aggregation criteria; see the dedicated page for details.

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  • Product types
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    Antibodies (510)
  • Target
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    CD152/CTLA4 & CD274/PD-L1 (1)
    Capsid protein VP2 (1)
    TRP-1 & CD47/MER6 (1)
    GP1 glycoprotein (2)
    TRP-1 & CD3e (1)
    E1 & E2 (gp35 & gp70) (3)
    CNR1/CB1 (3)
    EPO (1)
    iga/IgA1 protease (1)
    WNT2 (2)
    ATTR/Transthyretin amyloidosis (4)
    IL11 (2)
    GP/Envelopment polyprotein (1)
    TIGIT & CD274/PD-L1 (1)
    LRP6 (1)
    L1/Major capsid protein L1 (2)
    ACVRL1/ALK-1 & VEGFA (1)
    CD198/CCR8 (2)
    CD274/PD-L1 & CD134/OX40 (1)
    CD49d/ITGA4 (1)
    CDH1/CDH11 (1)
    Fluorescein & CD3E (1)
    CD137/4-1BB (2)
    ERBB3/HER3 (1)
    L2/Minor capsid protein L2 (2)
    APCS/PTX2 (1)
    CXCL11/I-TAC (1)
    CD20/MS4A1 (1)
    OSM/Oncostatin-M (1)
    ADM/Adrenomedullin (1)
    RSPO3 (1)
    CD73/NT5E (2)
    CD40/TNFRSF5 (1)
    Fusion glycoprotein F0 (4)
    CXCL4/PF4 (1)
    CCL3/MIP-1-alpha (1)
    Glycoprotein G (6)
    gH/UL75 (1)
    CCL11/Eotaxin (1)
    ENT2/SLC29A2 (1)
    CD152/CTLA4 (2)
    ANGPTL3 (1)
    MUC16/CA-125 (1)
    IL17A (4)
    VWF (1)
    Tityustoxin VII/Toxin VII/Ts7 (1)
    GPC (1)
    lukF (1)
    CD8a/Lyt2 (1)
    CD254/RANKL/TNFSF11 (1)
    GPRC5D (1)
    ApoC3 (1)
    CD16/CD32 (1)
    SOD1 (1)
    CCL1/I-309 (1)
    CTGF/CCN2 (1)
    Neuraminidase/NA (3)
    Capsid protein (2)
    G/Major surface glycoprotein G (2)
    CD283/TLR3 (2)
    MASP2 (1)
    APOE4 (1)
    gp125 (1)
    S-HBsAg/SHB (1)
    CD99 (1)
    IL12B/IL-12 p40 (1)
    RBD (S6P trimer) (3)
    gp120/Glycoprotein 120 (1)
    STEAP1 (1)
    TNFSF9/4-1BBL (2)
    NS1/gp68/gp70 (6)
    CD274/PD-L1 & CD28 (1)
    PTP4A1/PRL1 (1)
    FCGRT/FCRN (1)
    VP1/Coatprotein VP1 (2)
    CD307e/FCRL5 (1)
    CD152/CTLA4 & CD134/OX40 (1)
    PRLR (1)
    CSPG4/HMW-MAA/MCSP (1)
    PAUF (1)
    Pre-F/Fusion glycoprotein F0 (2)
    ANGPTL4 (2)
    CD122/IL2RB (1)
    Major surface glycoprotein G (3)
    PDGFC (1)
    Major capsid protein L1 (3)
    LGR5/GPR49 (1)
    TREM1 & CD46 (1)
    shiga toxin type 2A/stx2A (1)
    EGFR/ERBB1 & CD3E (1)
    AFP/Alpha-fetoprotein (1)
    Fusion glycoprotein (4)
    F8/Coagulation factor VIII (7)
    IL8/CXCL8 (1)
    aPC/Activated protein C (3)
    FGF21 (1)
    CD16a/FCGR3A (3)
    CCL14/NCC-2 (1)
    APOE3/4 (1)
    IL10 (1)
    Outer capsid protein VP4 (2)
    IL18/IL1F4 (1)
    C1S (1)
    RBD (Omicron/JN.1) (2)
    IL17F (1)
    GDF15/MIC1 (1)
    FedF (1)
    Prefusion Protein (2)
    TSLP (1)
    CXCL1/NAP-3/GRO-alpha (1)
    NA/Neuraminidase (1)
    CCL2/MCP-1 (1)
    BMP4 (1)
    Heparanase (1)
    CD120b/TNFR2 (1)
    BAG3 (1)
    TCRαβ/alpha-beta TCR (1)
    ARG1/Arginase-1 (2)
    shiga toxin type 2/stx2B (1)
    OPN/SPP1 (1)
    Fc Block (1)
    GP/Glycoprotein (5)
    LTA/TNF-beta (1)
    CD340/ERBB2 (1)
    gp140/Env Trimer (2)
    EGFRvIII & CD3E (1)
    wlaB/pglK (1)
    TREML1/TLT1 (1)
    CD20/MS4A1 & CD3E (1)
    CLDN3/Claudin-3 (1)
    ROR1/NTRKR1 (1)
    CXCL9/MIG (1)
    IL13 (1)
    FAP/FAPalpha (1)
    APOE2/3/4 (1)
    Pvs25 (1)
    entB/SEB (1)
    BTN3A (1)
    IL22 (1)
    gB/BALF4 (2)
    EGFL7 (1)
    Toxin B/tcdB (1)
    TGM2 (1)
    EGFRvIII-specific/EGFR variant III (2)
    HBsAg (5)
    SAA (2)
    Protease/PR (1)
    TSHR/LGR3 (2)
    IL9 (1)
    Outer capsid glycoprotein VP7 (1)
    PSCA (1)
    MUC5AC (1)
    GDF11/BMP11 (1)
    VLP (1)
    SNCA/Alpha-synuclein (5)
    Envelope protein E (7)
    Fluorescein & CD274/PD-L1 (1)
    IL2 (1)
    HGF (1)
    CD172a/SIRPA (3)
    FAP & CD3E (1)
    Glycoprotein C/Gc (2)
    CSF2/GM-CSF (1)
    IGF1 (2)
    GREM1/DAND2 (1)
    CFD (1)
    LAMP5 (1)
    PTP4A3/PRL3 (1)
    sLea/CA19-9 (1)
    MSLN/Mesothelin (1)
    CD340/ERBB2 & CD3E (2)
    IL5 (1)
    NGF/Beta-NGF (2)
    CD279/PD-1 & CD274/PD-L1 (1)
    CD4 (1)
    RBP2b (1)
    CD110/TPOR (2)
    IL1B/IL1F2 (1)
    TSG101 (2)
    ERVW-1/HERV-W-Env (1)
    CSF1/M-CSF (1)
    SFRP1 (1)
    STAT3 (1)
    CCL8/MCP-2 (1)
    CD115/CSF1R (1)
    ACE2 (2)
    Blood group Hantigen/Globo H (3)
    VSIG4/CRIg (1)
    Mature virion in Complex [(VP0/1/3)5]12 (2)
    IFNG/IFN-gamma (2)
    BDNF (1)
    CDH17/Cadherin-17 (1)
    CD335/NCR1/NKp46 (1)
    gE/Envelope glycoprotein E (1)
    HA/Hemagglutinin (7)
    cyaA/Cyclolysin (2)
    Capsid protein VP1 (2)
    Fusion glycoprotein/F Trimer (1)
    CD3E (2)
    PF45/48 (2)
    IL6R (1)
    IFNAR1 (1)
    CD279/PD-1 (8)
    VTCN1/B7-H4 (1)
    GFRAL (1)
    IL6 (2)
    IFNB1/IFN-beta (1)
    Alpha-toxin/hly (1)
    Fluorescein & CD47/MER6 (1)
    botA/BoNT (2)
    CD114/G-CSFR (1)
    TRP-1 & CD134/OX40 (1)
    Capsid protein VP1/VP3/VP4 (2)
    CD19 & CD3E (1)
    IL1A/IL1F1 (1)
    THPO/Thrombopoietin (1)
    shiga toxin type 1B/stx1B (1)
    APOE (1)
    CD228/MELTF (1)
    S2 Protein (1)
    TNFa/TNF-alpha (2)
    CD279/PD-1 & CD47/MER6 (1)
    IGF2 (1)
    S/Spike glycoprotein (1)
    ADAMTS4 (4)
    F2/Prothrombin/PIVKA-II (1)
    PDGFD (1)
    IL23A (1)
    IL21 (1)
    IL31RA (1)
    RAGE/AGER (3)
    CX3CL1/Fractalkine (1)
    IFNA1/Interferon alpha-D (1)
    CCL17/TARC (1)
    CD274/PD-L1 (5)
    IFN α2/IFNA2 (1)
    CD268/TNFRSF13C (2)
    CD314/KLRK1 & CD3E (1)
    HHRF3/US28 (1)
    VSIR/VISTA & CD274/PD-L1 (1)
    APP/Amyloid beta (1)
    VEGFA (1)
    HTRA1/PRSS11 (1)
    TIGIT (3)
    BMP2 (1)
    CD9 (1)
    Spike glycoprotein 2 (5)
    ROBO2 (1)
    ADGRE1/F4/80 & CD3E (1)
    CD274/PD-L1 & CD3E (1)
    PDGFB (1)
    CSF3/G-CSF (1)
    BMP6 (1)
    CD132/IL2RG (1)
    TGFB2/TGF-beta-2 (1)
    IL11RA (2)
    Intermediate capsid protein VP6 (1)
    L3/CP-H/Protein II (1)
    CCL24/Eotaxin-2/MPIF-2 (1)
    TPSAB1/Tryptase-1 (1)
    CD276/B7-H3 & CD3E (1)
    gH/gL Complexes (2)
    IL36RN/IL-1F5/IL-36Ra (1)
    env/Envpolyprotein (1)
    CXCL10/IP-10 (1)
    LRRC15/LIB (1)
    RBD (13)
    CXCL12/SDF-1 (1)
    IL20 (1)
    HSP90 (1)
    ProteinUL128 & UL131A (1)
    gB/UL27 (1)
    GPA33 (1)
    Flt3 ligand/FLT3LG (1)
    Procapsid [(VP0/1/3) 5] 12 (2)
    F/Fusion glycoprotein F0 (8)
    ADAMTS5 (2)
    F9/Factor IX (1)
    TGFA/TGF-alpha (1)
    HBEGF (1)
    GDF2/BMP9 (1)
    mature virion in complex (5)
    gH/Envelope glycoprotein H (2)
    NP/Nucleoprotein (3)
    CD200 & CD47/MER6 (1)
    P domain (1)
    Spike glycoprotein (1)
    Protein prM/prM (3)
    S2/Spike protein S2' (1)
    NS1/Non-structural protein 1 (1)
    Galectin-3/Gal-3 (1)
    EPOR (3)
    TGFB1 (2)
    CDH11 (1)
    BMP10 (1)
    CD37/TSPAN26 (1)
    TERM2 (1)
    env/Env polyprotein (4)
    CD274/PD-L1 & CD47/MER6 (1)
    Toxin A/tcdA (1)
    pro-MSTN/GDF8 (1)
    HLA-A*11:01 (1)
    S1 N-terminal domain/S1-NTD (1)
    CA9 (1)
    FOLH1/PSMA (1)
    gD/Envelope glycoprotein D (2)
    F12/Coagulationfactor XII (1)
    Capsid protein VP25 (1)
    CCL5/RANTES (1)
    SSEA4 (4)
    DPEP3 (1)
    CD79B & CD3E (1)
    SOST (1)
    GIPR/GIP-R (2)
    IL31 (4)
    KLKB1/KLK3 (1)
    CD52 (1)
    CD295/LEPR (1)
    NS1 (1)
    gB/Envelope glycoprotein B (8)
  • Species
    0 selected
    Staphylococcus aureus (3)
    Dobrava-Belgrade virus (DOBV) (2)
    Porcine circovirus 2 (PCV2) (2)
    Bovine respiratory syncytial virus (BRSV) (2)
    Hepatitis B virus genotype A (HBV-A) (6)
    Human immunodeficiency virus 1 (HIV-1) (10)
    Hepatitis C Virus (HCV) (9)
    Seoul virus (SEOV) (2)
    Human metapneumovirus (2)
    Human papillomavirus 58 (HPV58) (3)
    Rat (1)
    Human metapneumovirus (HMPV) (5)
    Rabbit (2)
    Rotavirus (RV) (1)
    E. coli (4)
    Japanese encephalitis virus (JEV) (1)
    Influenza B virus (Flu B) (1)
    Andes virus (ANDV) (2)
    Zaire ebolavirus (ZEBOV) (6)
    Coxsackievirus B1 (CBV1) (3)
    Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)
    Campylobacter jejuni subsp. (1)
    Human papillomavirus 59 (HPV59) (1)
    Human (224)
    Plasmodium vivax (2)
    Hendra virus (HeV) (2)
    Epstein-Barr virus (EBV/HHV-4) (2)
    Clostridioides difficile (2)
    Rotavirus A (RV-A) (4)
    Dengue virus type 2 (DENV-2) (9)
    Sin Nombre virus (SNV) (2)
    Human endogenous retroviruses W (HERV-W) (1)
    Chikungunya virus (CHIKV) (1)
    General (3)
    Influenza A virus (Flu A) (9)
    Bordetella pertussis (2)
    Poliovirus type 1 (PV1) (2)
    Plasmodium falciparum (2)
    Clostridium botulinum (2)
    Reston ebolavirus (REBOV) (1)
    Enterovirus D68 (EV-D68) (2)
    Junin mammarenavirus (JUNV) (1)
    Mouse (65)
    Human herpesvirus 1 (HSV-1/HHV-1) (5)
    Human cytomegalovirus (HCMV/HHV-5) (7)
    Bundibugyo ebolavirus (BDBV) (1)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (21)
    Monkey (1)
    Human adenovirus 3 (HAdV-3) (1)
    Varicella-zoster virus (VZV/HHV-3) (4)
    Suid alphaherpesvirus 1 (SuHV-1/PRV) (3)
    Dengue virus type 1 (DENV-1) (1)
    Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)
    Candida albicans (1)
    Hantaan virus (HTNV) (2)
    Enterovirus 71 (EV71) (4)
    Human respiratory syncytial virus (HRSV) (14)
    Coxsackievirus A16 (CVA16) (2)
    Tai Forest ebolavirus (TAFV) (1)
    Hepatitis E virus/HEV (1)
    Human parvovirus B19 (HPV B19) (3)
    Ebola virus (EBOV) (1)
    Cat (1)
    Human astrovirus-8 (HAtVs) (1)
    Dog (11)
    Dengue virus type 3 (DENV-3) (1)
    Zika virus (ZIKV) (2)
    Sudan ebolavirus (SEBOV) (1)
    Human hepatitis A virus (HHAV) (1)
    Puumala virus (PUUV) (2)
    Machupo virus (MACV) (1)
    Streptococcus pneumoniae (1)
    Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)
    Orthohantavirus puumalaense (PUUV) (1)
    Human papillomavirus 6 (HPV6) (1)
    Human papillomavirus 16 (HPV16) (2)
    Nipah virus (NiV) (13)
    Dengue virus type 4 (DENV-4) (1)
    Brazilian scorpion (1)
    Lassa virus (LASV) (1)
  • Applications
    0 selected
    IHC (6)
    Stimulatory (1)
    ELISA (424)
    IP (5)
    RIA (1)
    FACS (2)
    Nneutralization (1)
    Cell Deplete (1)
    Neutralization (388)
    ICC (1)
    in vivo blocking of PD-1/PD-L signaling (2)
    Functional assay (2)
    in vivo study (4)
    FuncS (55)
    in vivo (1)
    Blocking (41)
    T cell stimulation (Reported) (1)
    Agonist (8)
    Research in vivo (2)
    in vivo CD4+ T cell depletion (1)
    in vivo PD-L1 blockade (3)
    T cell depletion (Reported) (1)
    in vitro PD-L1 blockade (3)
    FCM (77)
    IHC-F (3)
    Antagonist (1)
     ELISA (1)
    WB (22)
    IF (8)
    DB (2)
    in vivo research (1)
    SPR (18)
  • Reactivity
    0 selected
    Coxsackievirus B1 (CVB1) (3)
    Influenza B virus (1)
    Chikungunya virus (1)
    Mouse (12)
    Human (16)
    Puumala virus (1)
  • Host species
    0 selected
    Rat (11)
    Alpaca (5)
    Mouse (161)
    Hamster (1)
    Human (319)
    Dog (8)
    Cat (1)
  • Clonality
    0 selected
    Monoclonal (510)
  • Conjugate
    0 selected
    Unconjugated (510)

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