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In Vivo Antibodies

abinScience in vivo antibodies are functional-grade reagents optimized for animal studies—azide-free, low endotoxin, sterile-filtered and aggregation-tested. Available in blocking, depleting, and neutralizing formats with lot-specific CoA reporting purity, endotoxin (LAL), and sterility. Includes IgG, F(ab')2, and Fc-engineered options. RUO

Why Researchers Choose abinScience

Animal-Compatible Azide-free, carrier-free, sterile buffer
Low Endotoxin LAL-tested, ≤0.1 EU/μg typical
Aggregation Control SEC-HPLC/DLS verified
Flexible Formats IgG, F(ab')2, Fc variants
Lot-Specific QC CoA with endotoxin, purity, sterility

Shop by Function

Shop by Application

Selection & Handling Guide

  1. Function: Select blocking, depleting, or neutralizing based on target and desired MoA.
  2. Format: Choose IgG for Fc-mediated effects (ADCC/CDC); F(ab')2 to eliminate FcγR binding.
  3. Dosing: Follow mg/kg guidelines from literature; common routes: i.p., i.v., s.c.
  4. QC Review: Check lot CoA for endotoxin, purity, and sterility before use.
  5. Controls: Always include matched isotype and vehicle controls.

Applications

Immunotherapy mechanism studies
Cell depletion in vivo
Cytokine blockade in disease models
Vaccine efficacy and immune modulation

Documents & QC

Lot-specific CoA: concentration, endotoxin, purity, sterility
Aggregation data (SEC-HPLC/DLS)
Recommended dosing and handling protocols

FAQs

How is an in vivo antibody different from standard lab grade?

In vivo products are azide-free, low endotoxin, sterile-filtered and aggregation-controlled, with carrier-free buffers and lot-level QC tailored to animal studies.

Should I choose IgG or F(ab')2?

Use IgG for Fc effector functions (depletion/engagement); use F(ab')2 when avoiding FcγR interactions is important.

Recommended endotoxin level?

Select low-endotoxin lots per protocol and record values from the lot-specific CoA; control endotoxin alongside dose and route.

Can these be used in humans?

No. All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic use.

What is InVivo Plus?

InVivo Plus is abinScience’s premium functional-grade specification with defined buffer, endotoxin and aggregation criteria; see the dedicated page for details.

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    Antibodies (510)
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    Capsid protein (2)
    Major surface glycoprotein G (3)
    CXCL10/IP-10 (1)
    CD254/RANKL/TNFSF11 (1)
    AFP/Alpha-fetoprotein (1)
    CD120b/TNFR2 (1)
    CXCL12/SDF-1 (1)
    GPA33 (1)
    ApoC3 (1)
    CCL24/Eotaxin-2/MPIF-2 (1)
    Fc Block (1)
    PTP4A1/PRL1 (1)
    LTA/TNF-beta (1)
    CSPG4/HMW-MAA/MCSP (1)
    NS1/gp68/gp70 (6)
    P domain (1)
    IL9 (1)
    Outer capsid glycoprotein VP7 (1)
    APOE4 (1)
    EPOR (3)
    HTRA1/PRSS11 (1)
    env/Env polyprotein (4)
    IL13 (1)
    CDH11 (1)
    CD37/TSPAN26 (1)
    ROBO2 (1)
    F/Fusion glycoprotein F0 (8)
    IL22 (1)
    RBD (S6P trimer) (3)
    mature virion in complex (5)
    F9/Factor IX (1)
    IL5 (1)
    NGF/Beta-NGF (2)
    TPSAB1/Tryptase-1 (1)
    CD274/PD-L1 & CD28 (1)
    IL1B/IL1F2 (1)
    CSF1/M-CSF (1)
    CD152/CTLA4 & CD134/OX40 (1)
    GDF11/BMP11 (1)
    IL2 (1)
    HGF (1)
    CSF2/GM-CSF (1)
    EGFR/ERBB1 & CD3E (1)
    CA9 (1)
    IGF1 (2)
    ProteinUL128 & UL131A (1)
    CCL5/RANTES (1)
    E1 & E2 (gp35 & gp70) (3)
    BMP4 (1)
    Procapsid [(VP0/1/3) 5] 12 (2)
    entB/SEB (1)
    Heparanase (1)
    CD16a/FCGR3A (3)
    APOE3/4 (1)
    gB/BALF4 (2)
    NP/Nucleoprotein (3)
    EGFL7 (1)
    Spike glycoprotein (1)
    GP/Envelopment polyprotein (1)
    S2/Spike protein S2' (1)
    HBsAg (5)
    RBD (Omicron/JN.1) (2)
    CD137/4-1BB (2)
    TSHR/LGR3 (2)
    CDH1/CDH11 (1)
    IFNG/IFN-gamma (2)
    TERM2 (1)
    Capsid protein VP2 (1)
    Prefusion Protein (2)
    Toxin A/tcdA (1)
    gE/Envelope glycoprotein E (1)
    NA/Neuraminidase (1)
    Pvs25 (1)
    CXCL4/PF4 (1)
    TNFa/TNF-alpha (2)
    CCL3/MIP-1-alpha (1)
    CCL11/Eotaxin (1)
    IGF2 (1)
    LAMP5 (1)
    ADAMTS4 (4)
    Capsid protein VP25 (1)
    PTP4A3/PRL3 (1)
    PDGFD (1)
    CD279/PD-1 (8)
    SOST (1)
    IL6 (2)
    RBP2b (1)
    KLKB1/KLK3 (1)
    CD52 (1)
    ERVW-1/HERV-W-Env (1)
    CD295/LEPR (1)
    CXCL11/I-TAC (1)
    SFRP1 (1)
    EGFRvIII & CD3E (1)
    OSM/Oncostatin-M (1)
    NS1 (1)
    IL1A/IL1F1 (1)
    SNCA/Alpha-synuclein (5)
    CD20/MS4A1 & CD3E (1)
    THPO/Thrombopoietin (1)
    IFNA1/Interferon alpha-D (1)
    VSIG4/CRIg (1)
    CCL1/I-309 (1)
    CD274/PD-L1 (5)
    ROR1/NTRKR1 (1)
    CNR1/CB1 (3)
    HA/Hemagglutinin (7)
    APOE2/3/4 (1)
    IL23A (1)
    cyaA/Cyclolysin (2)
    BTN3A (1)
    IL21 (1)
    lukF (1)
    LRP6 (1)
    EGFRvIII-specific/EGFR variant III (2)
    CD49d/ITGA4 (1)
    Protease/PR (1)
    GPRC5D (1)
    TSG101 (2)
    ERBB3/HER3 (1)
    CD20/MS4A1 (1)
    PDGFB (1)
    VLP (1)
    CSF3/G-CSF (1)
    BMP6 (1)
    Fluorescein & CD274/PD-L1 (1)
    TGFB2/TGF-beta-2 (1)
    IFN α2/IFNA2 (1)
    RSPO3 (1)
    Fusion glycoprotein F0 (4)
    gH/UL75 (1)
    MUC16/CA-125 (1)
    VEGFA (1)
    CD340/ERBB2 & CD3E (2)
    BMP2 (1)
    CD279/PD-1 & CD274/PD-L1 (1)
    botA/BoNT (2)
    Pre-F/Fusion glycoprotein F0 (2)
    PF45/48 (2)
    IL6R (1)
    LGR5/GPR49 (1)
    CD115/CSF1R (1)
    F8/Coagulation factor VIII (7)
    IL20 (1)
    Blood group Hantigen/Globo H (3)
    Fusion glycoprotein (4)
    Intermediate capsid protein VP6 (1)
    Mature virion in Complex [(VP0/1/3)5]12 (2)
    CDH17/Cadherin-17 (1)
    aPC/Activated protein C (3)
    CD335/NCR1/NKp46 (1)
    CD307e/FCRL5 (1)
    PRLR (1)
    gH/gL Complexes (2)
    ANGPTL4 (2)
    IL36RN/IL-1F5/IL-36Ra (1)
    CD122/IL2RB (1)
    env/Envpolyprotein (1)
    Fusion glycoprotein/F Trimer (1)
    CD3E (2)
    TGFB1 (2)
    MASP2 (1)
    APP/Amyloid beta (1)
    gp125 (1)
    BMP10 (1)
    CD99 (1)
    TSLP (1)
    CXCL1/NAP-3/GRO-alpha (1)
    Spike glycoprotein 2 (5)
    Fluorescein & CD47/MER6 (1)
    CCL2/MCP-1 (1)
    Flt3 ligand/FLT3LG (1)
    TRP-1 & CD134/OX40 (1)
    ADAMTS5 (2)
    TGFA/TGF-alpha (1)
    CD19 & CD3E (1)
    HBEGF (1)
    CCL14/NCC-2 (1)
    GDF2/BMP9 (1)
    CD268/TNFRSF13C (2)
    NS1/Non-structural protein 1 (1)
    CD279/PD-1 & CD47/MER6 (1)
    CD283/TLR3 (2)
    FCGRT/FCRN (1)
    gp140/Env Trimer (2)
    PAUF (1)
    gB/Envelope glycoprotein B (8)
    TREML1/TLT1 (1)
    TREM1 & CD46 (1)
    RBD (13)
    shiga toxin type 2A/stx2A (1)
    IL31RA (1)
    BAG3 (1)
    gD/Envelope glycoprotein D (2)
    HSP90 (1)
    RAGE/AGER (3)
    TCRαβ/alpha-beta TCR (1)
    ARG1/Arginase-1 (2)
    GIPR/GIP-R (2)
    OPN/SPP1 (1)
    L1/Major capsid protein L1 (2)
    gH/Envelope glycoprotein H (2)
    CD314/KLRK1 & CD3E (1)
    C1S (1)
    Protein prM/prM (3)
    VSIR/VISTA & CD274/PD-L1 (1)
    FedF (1)
    PSCA (1)
    TIGIT (3)
    CXCL9/MIG (1)
    EPO (1)
    FAP/FAPalpha (1)
    pro-MSTN/GDF8 (1)
    ATTR/Transthyretin amyloidosis (4)
    ADGRE1/F4/80 & CD3E (1)
    CD274/PD-L1 & CD3E (1)
    FOLH1/PSMA (1)
    CD172a/SIRPA (3)
    F12/Coagulationfactor XII (1)
    CD152/CTLA4 (2)
    FAP & CD3E (1)
    gB/UL27 (1)
    Glycoprotein C/Gc (2)
    CFD (1)
    IL17A (4)
    sLea/CA19-9 (1)
    IL11RA (2)
    DPEP3 (1)
    L3/CP-H/Protein II (1)
    shiga toxin type 2/stx2B (1)
    GP/Glycoprotein (5)
    MSLN/Mesothelin (1)
    CD340/ERBB2 (1)
    L2/Minor capsid protein L2 (2)
    CD4 (1)
    CD276/B7-H3 & CD3E (1)
    STAT3 (1)
    CD110/TPOR (2)
    wlaB/pglK (1)
    Envelope protein E (7)
    CLDN3/Claudin-3 (1)
    LRRC15/LIB (1)
    S1 N-terminal domain/S1-NTD (1)
    GREM1/DAND2 (1)
    CD274/PD-L1 & CD47/MER6 (1)
    CCL8/MCP-2 (1)
    CD200 & CD47/MER6 (1)
    Toxin B/tcdB (1)
    TGM2 (1)
    Galectin-3/Gal-3 (1)
    SAA (2)
    CD16/CD32 (1)
    MUC5AC (1)
    BDNF (1)
    GP1 glycoprotein (2)
    CTGF/CCN2 (1)
    ADM/Adrenomedullin (1)
    CD114/G-CSFR (1)
    Capsid protein VP1/VP3/VP4 (2)
    HLA-A*11:01 (1)
    CD73/NT5E (2)
    APOE (1)
    CD40/TNFRSF5 (1)
    CD228/MELTF (1)
    gp120/Glycoprotein 120 (1)
    ENT2/SLC29A2 (1)
    ANGPTL3 (1)
    S2 Protein (1)
    SSEA4 (4)
    F2/Prothrombin/PIVKA-II (1)
    Tityustoxin VII/Toxin VII/Ts7 (1)
    CD79B & CD3E (1)
    S/Spike glycoprotein (1)
    GFRAL (1)
    IL31 (4)
    VTCN1/B7-H4 (1)
    APCS/PTX2 (1)
    IL12B/IL-12 p40 (1)
    CD198/CCR8 (2)
    CD274/PD-L1 & CD134/OX40 (1)
    ACE2 (2)
    Fluorescein & CD3E (1)
    IL8/CXCL8 (1)
    CD152/CTLA4 & CD274/PD-L1 (1)
    CX3CL1/Fractalkine (1)
    TRP-1 & CD47/MER6 (1)
    CCL17/TARC (1)
    SOD1 (1)
    FGF21 (1)
    TRP-1 & CD3e (1)
    VP1/Coatprotein VP1 (2)
    Neuraminidase/NA (3)
    iga/IgA1 protease (1)
    WNT2 (2)
    G/Major surface glycoprotein G (2)
    IL11 (2)
    Capsid protein VP1 (2)
    PDGFC (1)
    Major capsid protein L1 (3)
    CD8a/Lyt2 (1)
    TIGIT & CD274/PD-L1 (1)
    ACVRL1/ALK-1 & VEGFA (1)
    GPC (1)
    IFNB1/IFN-beta (1)
    Alpha-toxin/hly (1)
    CD9 (1)
    CD132/IL2RG (1)
    IL10 (1)
    shiga toxin type 1B/stx1B (1)
    Outer capsid protein VP4 (2)
    IL18/IL1F4 (1)
    HHRF3/US28 (1)
    STEAP1 (1)
    TNFSF9/4-1BBL (2)
    Glycoprotein G (6)
    IL17F (1)
    GDF15/MIC1 (1)
    IFNAR1 (1)
    VWF (1)
    S-HBsAg/SHB (1)
  • Species
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    Suid alphaherpesvirus 1 (SuHV-1/PRV) (3)
    Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)
    Enterovirus 71 (EV71) (4)
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    Tai Forest ebolavirus (TAFV) (1)
    Orthohantavirus puumalaense (PUUV) (1)
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    Puumala virus (PUUV) (2)
    Ebola virus (EBOV) (1)
    Plasmodium vivax (2)
    Human astrovirus-8 (HAtVs) (1)
    Mouse (65)
    Dog (11)
    Human endogenous retroviruses W (HERV-W) (1)
    Zika virus (ZIKV) (2)
    Influenza A virus (Flu A) (9)
    Bordetella pertussis (2)
    Human herpesvirus 1 (HSV-1/HHV-1) (5)
    Hendra virus (HeV) (2)
    Staphylococcus aureus (3)
    Dobrava-Belgrade virus (DOBV) (2)
    Sudan ebolavirus (SEBOV) (1)
    Chikungunya virus (CHIKV) (1)
    Nipah virus (NiV) (13)
    Junin mammarenavirus (JUNV) (1)
    Clostridium botulinum (2)
    Rat (1)
    General (3)
    Human metapneumovirus (HMPV) (5)
    Rabbit (2)
    Varicella-zoster virus (VZV/HHV-3) (4)
    Seoul virus (SEOV) (2)
    Human metapneumovirus (2)
    Plasmodium falciparum (2)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (21)
    Human parvovirus B19 (HPV B19) (3)
    Coxsackievirus B1 (CBV1) (3)
    Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)
    Candida albicans (1)
    Andes virus (ANDV) (2)
    Human papillomavirus 6 (HPV6) (1)
    E. coli (4)
    Japanese encephalitis virus (JEV) (1)
    Sin Nombre virus (SNV) (2)
    Human adenovirus 3 (HAdV-3) (1)
    Zaire ebolavirus (ZEBOV) (6)
    Human papillomavirus 16 (HPV16) (2)
    Campylobacter jejuni subsp. (1)
    Dengue virus type 2 (DENV-2) (9)
    Dengue virus type 1 (DENV-1) (1)
    Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)
    Clostridioides difficile (2)
    Machupo virus (MACV) (1)
    Enterovirus D68 (EV-D68) (2)
    Cat (1)
    Human immunodeficiency virus 1 (HIV-1) (10)
    Brazilian scorpion (1)
    Dengue virus type 3 (DENV-3) (1)
    Streptococcus pneumoniae (1)
    Bovine respiratory syncytial virus (BRSV) (2)
    Poliovirus type 1 (PV1) (2)
    Human papillomavirus 58 (HPV58) (3)
    Reston ebolavirus (REBOV) (1)
    Rotavirus (RV) (1)
    Human cytomegalovirus (HCMV/HHV-5) (7)
    Dengue virus type 4 (DENV-4) (1)
    Hepatitis B virus genotype A (HBV-A) (6)
    Lassa virus (LASV) (1)
    Human papillomavirus 59 (HPV59) (1)
    Human (224)
    Porcine circovirus 2 (PCV2) (2)
    Hepatitis C Virus (HCV) (9)
    Hepatitis E virus/HEV (1)
    Rotavirus A (RV-A) (4)
    Bundibugyo ebolavirus (BDBV) (1)
    Monkey (1)
    Influenza B virus (Flu B) (1)
    Human respiratory syncytial virus (HRSV) (14)
    Hantaan virus (HTNV) (2)
    Coxsackievirus A16 (CVA16) (2)
  • Applications
    0 selected
    in vivo study (4)
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    Agonist (8)
    ICC (1)
    in vivo blocking of PD-1/PD-L signaling (2)
    Functional assay (2)
    FCM (77)
    in vivo PD-L1 blockade (3)
    FuncS (55)
    Stimulatory (1)
    in vivo (1)
    T cell stimulation (Reported) (1)
    Research in vivo (2)
    in vitro PD-L1 blockade (3)
    T cell depletion (Reported) (1)
    WB (22)
    IHC-F (3)
    SPR (18)
    in vivo CD4+ T cell depletion (1)
    IF (8)
    ELISA (424)
    DB (2)
    in vivo research (1)
    Neutralization (388)
    IP (5)
    IHC (6)
    Antagonist (1)
    Cell Deplete (1)
    Nneutralization (1)
    RIA (1)
    FACS (2)
     ELISA (1)
  • Reactivity
    0 selected
    Influenza B virus (1)
    Chikungunya virus (1)
    Mouse (12)
    Coxsackievirus B1 (CVB1) (3)
    Human (16)
    Puumala virus (1)
  • Host species
    0 selected
    Dog (8)
    Mouse (161)
    Human (319)
    Hamster (1)
    Cat (1)
    Alpaca (5)
    Rat (11)
  • Clonality
    0 selected
    Monoclonal (510)
  • Conjugate
    0 selected
    Unconjugated (510)

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