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In Vivo Antibodies

abinScience in vivo antibodies are functional-grade reagents optimized for animal studies—azide-free, low endotoxin, sterile-filtered and aggregation-tested. Available in blocking, depleting, and neutralizing formats with lot-specific CoA reporting purity, endotoxin (LAL), and sterility. Includes IgG, F(ab')2, and Fc-engineered options. RUO

Why Researchers Choose abinScience

Animal-Compatible Azide-free, carrier-free, sterile buffer
Low Endotoxin LAL-tested, ≤0.1 EU/μg typical
Aggregation Control SEC-HPLC/DLS verified
Flexible Formats IgG, F(ab')2, Fc variants
Lot-Specific QC CoA with endotoxin, purity, sterility

Shop by Function

Shop by Application

Selection & Handling Guide

  1. Function: Select blocking, depleting, or neutralizing based on target and desired MoA.
  2. Format: Choose IgG for Fc-mediated effects (ADCC/CDC); F(ab')2 to eliminate FcγR binding.
  3. Dosing: Follow mg/kg guidelines from literature; common routes: i.p., i.v., s.c.
  4. QC Review: Check lot CoA for endotoxin, purity, and sterility before use.
  5. Controls: Always include matched isotype and vehicle controls.

Applications

Immunotherapy mechanism studies
Cell depletion in vivo
Cytokine blockade in disease models
Vaccine efficacy and immune modulation

Documents & QC

Lot-specific CoA: concentration, endotoxin, purity, sterility
Aggregation data (SEC-HPLC/DLS)
Recommended dosing and handling protocols

FAQs

How is an in vivo antibody different from standard lab grade?

In vivo products are azide-free, low endotoxin, sterile-filtered and aggregation-controlled, with carrier-free buffers and lot-level QC tailored to animal studies.

Should I choose IgG or F(ab')2?

Use IgG for Fc effector functions (depletion/engagement); use F(ab')2 when avoiding FcγR interactions is important.

Recommended endotoxin level?

Select low-endotoxin lots per protocol and record values from the lot-specific CoA; control endotoxin alongside dose and route.

Can these be used in humans?

No. All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic use.

What is InVivo Plus?

InVivo Plus is abinScience’s premium functional-grade specification with defined buffer, endotoxin and aggregation criteria; see the dedicated page for details.

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    Antibodies (510)
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    CNR1/CB1 (3)
    HBEGF (1)
    iga/IgA1 protease (1)
    GDF2/BMP9 (1)
    WNT2 (2)
    mature virion in complex (5)
    gH/Envelope glycoprotein H (2)
    E1 & E2 (gp35 & gp70) (3)
    IL11 (2)
    NS1/Non-structural protein 1 (1)
    TGFB1 (2)
    TIGIT & CD274/PD-L1 (1)
    LRP6 (1)
    ACVRL1/ALK-1 & VEGFA (1)
    BMP10 (1)
    CD198/CCR8 (2)
    GP/Envelopment polyprotein (1)
    env/Env polyprotein (4)
    CD274/PD-L1 & CD134/OX40 (1)
    CD49d/ITGA4 (1)
    Fluorescein & CD3E (1)
    CD152/CTLA4 & CD274/PD-L1 (1)
    TRP-1 & CD47/MER6 (1)
    CDH1/CDH11 (1)
    Flt3 ligand/FLT3LG (1)
    GP1 glycoprotein (2)
    F/Fusion glycoprotein F0 (8)
    Capsid protein VP2 (1)
    ADAMTS5 (2)
    TRP-1 & CD3e (1)
    TGFA/TGF-alpha (1)
    F12/Coagulationfactor XII (1)
    CCL5/RANTES (1)
    RSPO3 (1)
    Fusion glycoprotein F0 (4)
    DPEP3 (1)
    GIPR/GIP-R (2)
    Glycoprotein G (6)
    gH/UL75 (1)
    MUC16/CA-125 (1)
    VWF (1)
    GPC (1)
    gB/Envelope glycoprotein B (8)
    ERBB3/HER3 (1)
    CD20/MS4A1 (1)
    S1 N-terminal domain/S1-NTD (1)
    CA9 (1)
    FOLH1/PSMA (1)
    gD/Envelope glycoprotein D (2)
    EPO (1)
    ApoC3 (1)
    ATTR/Transthyretin amyloidosis (4)
    L1/Major capsid protein L1 (2)
    Capsid protein (2)
    G/Major surface glycoprotein G (2)
    CD137/4-1BB (2)
    CD254/RANKL/TNFSF11 (1)
    ADM/Adrenomedullin (1)
    CD73/NT5E (2)
    CD40/TNFRSF5 (1)
    CXCL4/PF4 (1)
    CCL3/MIP-1-alpha (1)
    CCL11/Eotaxin (1)
    ENT2/SLC29A2 (1)
    CD152/CTLA4 (2)
    ANGPTL3 (1)
    RBD (S6P trimer) (3)
    IL17A (4)
    Tityustoxin VII/Toxin VII/Ts7 (1)
    NS1/gp68/gp70 (6)
    CD283/TLR3 (2)
    MASP2 (1)
    APOE4 (1)
    L2/Minor capsid protein L2 (2)
    APCS/PTX2 (1)
    gp125 (1)
    CXCL11/I-TAC (1)
    CD99 (1)
    OSM/Oncostatin-M (1)
    Major surface glycoprotein G (3)
    Pre-F/Fusion glycoprotein F0 (2)
    GPRC5D (1)
    TREM1 & CD46 (1)
    CD16/CD32 (1)
    shiga toxin type 2A/stx2A (1)
    EGFR/ERBB1 & CD3E (1)
    SOD1 (1)
    CCL1/I-309 (1)
    AFP/Alpha-fetoprotein (1)
    CTGF/CCN2 (1)
    Neuraminidase/NA (3)
    Fusion glycoprotein (4)
    CD274/PD-L1 & CD28 (1)
    PTP4A1/PRL1 (1)
    aPC/Activated protein C (3)
    FCGRT/FCRN (1)
    lukF (1)
    CD152/CTLA4 & CD134/OX40 (1)
    CD8a/Lyt2 (1)
    CSPG4/HMW-MAA/MCSP (1)
    PAUF (1)
    RBD (Omicron/JN.1) (2)
    FedF (1)
    IL12B/IL-12 p40 (1)
    Prefusion Protein (2)
    NA/Neuraminidase (1)
    BMP4 (1)
    gp120/Glycoprotein 120 (1)
    STEAP1 (1)
    TNFSF9/4-1BBL (2)
    Heparanase (1)
    CD16a/FCGR3A (3)
    APOE3/4 (1)
    S-HBsAg/SHB (1)
    C1S (1)
    ANGPTL4 (2)
    shiga toxin type 2/stx2B (1)
    GP/Glycoprotein (5)
    CD122/IL2RB (1)
    CD340/ERBB2 (1)
    PDGFC (1)
    Major capsid protein L1 (3)
    LGR5/GPR49 (1)
    EGFRvIII & CD3E (1)
    F8/Coagulation factor VIII (7)
    wlaB/pglK (1)
    CD20/MS4A1 & CD3E (1)
    IL8/CXCL8 (1)
    CLDN3/Claudin-3 (1)
    FGF21 (1)
    VP1/Coatprotein VP1 (2)
    CD307e/FCRL5 (1)
    PRLR (1)
    TCRαβ/alpha-beta TCR (1)
    BTN3A (1)
    IL17F (1)
    GDF15/MIC1 (1)
    Toxin B/tcdB (1)
    TGM2 (1)
    EGFRvIII-specific/EGFR variant III (2)
    TSLP (1)
    SAA (2)
    Protease/PR (1)
    CXCL1/NAP-3/GRO-alpha (1)
    CCL2/MCP-1 (1)
    MUC5AC (1)
    ROR1/NTRKR1 (1)
    CCL14/NCC-2 (1)
    APOE2/3/4 (1)
    IL10 (1)
    Outer capsid protein VP4 (2)
    IL18/IL1F4 (1)
    ARG1/Arginase-1 (2)
    OPN/SPP1 (1)
    Fc Block (1)
    CD172a/SIRPA (3)
    FAP & CD3E (1)
    Glycoprotein C/Gc (2)
    LTA/TNF-beta (1)
    LAMP5 (1)
    PTP4A3/PRL3 (1)
    gp140/Env Trimer (2)
    CD340/ERBB2 & CD3E (2)
    CD279/PD-1 & CD274/PD-L1 (1)
    RBP2b (1)
    TREML1/TLT1 (1)
    MSLN/Mesothelin (1)
    TSG101 (2)
    CD4 (1)
    ERVW-1/HERV-W-Env (1)
    SFRP1 (1)
    CD110/TPOR (2)
    VLP (1)
    CD120b/TNFR2 (1)
    BAG3 (1)
    SNCA/Alpha-synuclein (5)
    Fluorescein & CD274/PD-L1 (1)
    Mature virion in Complex [(VP0/1/3)5]12 (2)
    CDH17/Cadherin-17 (1)
    entB/SEB (1)
    CD335/NCR1/NKp46 (1)
    IL22 (1)
    gB/BALF4 (2)
    EGFL7 (1)
    Capsid protein VP1 (2)
    HBsAg (5)
    Fusion glycoprotein/F Trimer (1)
    CD3E (2)
    TSHR/LGR3 (2)
    PF45/48 (2)
    IL6R (1)
    IL9 (1)
    Outer capsid glycoprotein VP7 (1)
    CD115/CSF1R (1)
    PSCA (1)
    CXCL9/MIG (1)
    ACE2 (2)
    IL13 (1)
    Blood group Hantigen/Globo H (3)
    FAP/FAPalpha (1)
    Pvs25 (1)
    TRP-1 & CD134/OX40 (1)
    CSF2/GM-CSF (1)
    CD19 & CD3E (1)
    CD114/G-CSFR (1)
    IGF1 (2)
    GREM1/DAND2 (1)
    CFD (1)
    Capsid protein VP1/VP3/VP4 (2)
    sLea/CA19-9 (1)
    shiga toxin type 1B/stx1B (1)
    IL5 (1)
    NGF/Beta-NGF (2)
    CD279/PD-1 & CD47/MER6 (1)
    S2 Protein (1)
    IL1B/IL1F2 (1)
    CSF1/M-CSF (1)
    IFNAR1 (1)
    STAT3 (1)
    GDF11/BMP11 (1)
    S/Spike glycoprotein (1)
    IFNB1/IFN-beta (1)
    Envelope protein E (7)
    Alpha-toxin/hly (1)
    Fluorescein & CD47/MER6 (1)
    botA/BoNT (2)
    VTCN1/B7-H4 (1)
    IL2 (1)
    HGF (1)
    VSIG4/CRIg (1)
    IL31RA (1)
    IFNG/IFN-gamma (2)
    BDNF (1)
    RAGE/AGER (3)
    gE/Envelope glycoprotein E (1)
    HA/Hemagglutinin (7)
    cyaA/Cyclolysin (2)
    CCL8/MCP-2 (1)
    APP/Amyloid beta (1)
    HTRA1/PRSS11 (1)
    TIGIT (3)
    IL1A/IL1F1 (1)
    Spike glycoprotein 2 (5)
    ROBO2 (1)
    THPO/Thrombopoietin (1)
    APOE (1)
    CD228/MELTF (1)
    ADGRE1/F4/80 & CD3E (1)
    CD9 (1)
    TNFa/TNF-alpha (2)
    CD274/PD-L1 & CD3E (1)
    IGF2 (1)
    ADAMTS4 (4)
    F2/Prothrombin/PIVKA-II (1)
    CD268/TNFRSF13C (2)
    CD314/KLRK1 & CD3E (1)
    PDGFD (1)
    CD279/PD-1 (8)
    GFRAL (1)
    IL6 (2)
    VSIR/VISTA & CD274/PD-L1 (1)
    CD276/B7-H3 & CD3E (1)
    CX3CL1/Fractalkine (1)
    LRRC15/LIB (1)
    IFNA1/Interferon alpha-D (1)
    CCL17/TARC (1)
    CD274/PD-L1 (5)
    ProteinUL128 & UL131A (1)
    gB/UL27 (1)
    IL11RA (2)
    L3/CP-H/Protein II (1)
    IL23A (1)
    TPSAB1/Tryptase-1 (1)
    IL21 (1)
    F9/Factor IX (1)
    NP/Nucleoprotein (3)
    CD200 & CD47/MER6 (1)
    VEGFA (1)
    Spike glycoprotein (1)
    Protein prM/prM (3)
    S2/Spike protein S2' (1)
    BMP2 (1)
    Galectin-3/Gal-3 (1)
    P domain (1)
    EPOR (3)
    TERM2 (1)
    CD274/PD-L1 & CD47/MER6 (1)
    PDGFB (1)
    CDH11 (1)
    CSF3/G-CSF (1)
    Toxin A/tcdA (1)
    BMP6 (1)
    pro-MSTN/GDF8 (1)
    CD37/TSPAN26 (1)
    CD132/IL2RG (1)
    TGFB2/TGF-beta-2 (1)
    IFN α2/IFNA2 (1)
    HHRF3/US28 (1)
    Procapsid [(VP0/1/3) 5] 12 (2)
    Capsid protein VP25 (1)
    SSEA4 (4)
    gH/gL Complexes (2)
    CD79B & CD3E (1)
    SOST (1)
    IL36RN/IL-1F5/IL-36Ra (1)
    IL31 (4)
    KLKB1/KLK3 (1)
    env/Envpolyprotein (1)
    CXCL10/IP-10 (1)
    CD52 (1)
    CD295/LEPR (1)
    RBD (13)
    NS1 (1)
    CXCL12/SDF-1 (1)
    IL20 (1)
    HSP90 (1)
    GPA33 (1)
    HLA-A*11:01 (1)
    Intermediate capsid protein VP6 (1)
    CCL24/Eotaxin-2/MPIF-2 (1)
  • Species
    0 selected
    Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)
    Human papillomavirus 6 (HPV6) (1)
    Porcine circovirus 2 (PCV2) (2)
    Bovine respiratory syncytial virus (BRSV) (2)
    Dobrava-Belgrade virus (DOBV) (2)
    Brazilian scorpion (1)
    Hepatitis C Virus (HCV) (9)
    Human papillomavirus 16 (HPV16) (2)
    Seoul virus (SEOV) (2)
    Human metapneumovirus (2)
    Rat (1)
    Human metapneumovirus (HMPV) (5)
    Rabbit (2)
    Staphylococcus aureus (3)
    E. coli (4)
    Japanese encephalitis virus (JEV) (1)
    Human immunodeficiency virus 1 (HIV-1) (10)
    Hepatitis B virus genotype A (HBV-A) (6)
    Zaire ebolavirus (ZEBOV) (6)
    Andes virus (ANDV) (2)
    Human papillomavirus 58 (HPV58) (3)
    Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)
    Campylobacter jejuni subsp. (1)
    Hendra virus (HeV) (2)
    Clostridioides difficile (2)
    Influenza B virus (Flu B) (1)
    Rotavirus (RV) (1)
    Sin Nombre virus (SNV) (2)
    Coxsackievirus B1 (CBV1) (3)
    Human endogenous retroviruses W (HERV-W) (1)
    Human papillomavirus 59 (HPV59) (1)
    Chikungunya virus (CHIKV) (1)
    Human (224)
    Epstein-Barr virus (EBV/HHV-4) (2)
    Poliovirus type 1 (PV1) (2)
    Plasmodium falciparum (2)
    Rotavirus A (RV-A) (4)
    General (3)
    Plasmodium vivax (2)
    Enterovirus D68 (EV-D68) (2)
    Junin mammarenavirus (JUNV) (1)
    Dengue virus type 2 (DENV-2) (9)
    Clostridium botulinum (2)
    Reston ebolavirus (REBOV) (1)
    Influenza A virus (Flu A) (9)
    Bordetella pertussis (2)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (21)
    Monkey (1)
    Mouse (65)
    Bundibugyo ebolavirus (BDBV) (1)
    Suid alphaherpesvirus 1 (SuHV-1/PRV) (3)
    Dengue virus type 1 (DENV-1) (1)
    Human adenovirus 3 (HAdV-3) (1)
    Human herpesvirus 1 (HSV-1/HHV-1) (5)
    Tai Forest ebolavirus (TAFV) (1)
    Hepatitis E virus/HEV (1)
    Ebola virus (EBOV) (1)
    Human cytomegalovirus (HCMV/HHV-5) (7)
    Enterovirus 71 (EV71) (4)
    Hantaan virus (HTNV) (2)
    Varicella-zoster virus (VZV/HHV-3) (4)
    Dog (11)
    Dengue virus type 3 (DENV-3) (1)
    Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)
    Zika virus (ZIKV) (2)
    Candida albicans (1)
    Cat (1)
    Human astrovirus-8 (HAtVs) (1)
    Streptococcus pneumoniae (1)
    Coxsackievirus A16 (CVA16) (2)
    Human parvovirus B19 (HPV B19) (3)
    Orthohantavirus puumalaense (PUUV) (1)
    Sudan ebolavirus (SEBOV) (1)
    Machupo virus (MACV) (1)
    Human respiratory syncytial virus (HRSV) (14)
    Human hepatitis A virus (HHAV) (1)
    Puumala virus (PUUV) (2)
    Nipah virus (NiV) (13)
    Dengue virus type 4 (DENV-4) (1)
    Lassa virus (LASV) (1)
  • Applications
    0 selected
    SPR (18)
    Stimulatory (1)
    IP (5)
    IHC (6)
    RIA (1)
    FACS (2)
    Nneutralization (1)
    ELISA (424)
    Cell Deplete (1)
    ICC (1)
    in vivo blocking of PD-1/PD-L signaling (2)
    Functional assay (2)
    in vivo study (4)
    Neutralization (388)
    in vivo (1)
    T cell stimulation (Reported) (1)
    Research in vivo (2)
    FuncS (55)
    in vivo CD4+ T cell depletion (1)
    in vivo PD-L1 blockade (3)
    Blocking (41)
    T cell depletion (Reported) (1)
    Agonist (8)
    in vitro PD-L1 blockade (3)
    Antagonist (1)
    FCM (77)
    IHC-F (3)
     ELISA (1)
    in vivo research (1)
    DB (2)
    WB (22)
    IF (8)
  • Reactivity
    0 selected
    Influenza B virus (1)
    Coxsackievirus B1 (CVB1) (3)
    Chikungunya virus (1)
    Mouse (12)
    Puumala virus (1)
    Human (16)
  • Host species
    0 selected
    Rat (11)
    Hamster (1)
    Alpaca (5)
    Mouse (161)
    Dog (8)
    Cat (1)
    Human (319)
  • Clonality
    0 selected
    Monoclonal (510)
  • Conjugate
    0 selected
    Unconjugated (510)

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