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In Vivo Antibodies

abinScience in vivo antibodies are functional-grade reagents optimized for animal studies—azide-free, low endotoxin, sterile-filtered and aggregation-tested. Available in blocking, depleting, and neutralizing formats with lot-specific CoA reporting purity, endotoxin (LAL), and sterility. Includes IgG, F(ab')2, and Fc-engineered options. RUO

Why Researchers Choose abinScience

Animal-Compatible Azide-free, carrier-free, sterile buffer
Low Endotoxin LAL-tested, ≤0.1 EU/μg typical
Aggregation Control SEC-HPLC/DLS verified
Flexible Formats IgG, F(ab')2, Fc variants
Lot-Specific QC CoA with endotoxin, purity, sterility

Shop by Function

Shop by Application

Selection & Handling Guide

  1. Function: Select blocking, depleting, or neutralizing based on target and desired MoA.
  2. Format: Choose IgG for Fc-mediated effects (ADCC/CDC); F(ab')2 to eliminate FcγR binding.
  3. Dosing: Follow mg/kg guidelines from literature; common routes: i.p., i.v., s.c.
  4. QC Review: Check lot CoA for endotoxin, purity, and sterility before use.
  5. Controls: Always include matched isotype and vehicle controls.

Applications

Immunotherapy mechanism studies
Cell depletion in vivo
Cytokine blockade in disease models
Vaccine efficacy and immune modulation

Documents & QC

Lot-specific CoA: concentration, endotoxin, purity, sterility
Aggregation data (SEC-HPLC/DLS)
Recommended dosing and handling protocols

FAQs

How is an in vivo antibody different from standard lab grade?

In vivo products are azide-free, low endotoxin, sterile-filtered and aggregation-controlled, with carrier-free buffers and lot-level QC tailored to animal studies.

Should I choose IgG or F(ab')2?

Use IgG for Fc effector functions (depletion/engagement); use F(ab')2 when avoiding FcγR interactions is important.

Recommended endotoxin level?

Select low-endotoxin lots per protocol and record values from the lot-specific CoA; control endotoxin alongside dose and route.

Can these be used in humans?

No. All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic use.

What is InVivo Plus?

InVivo Plus is abinScience’s premium functional-grade specification with defined buffer, endotoxin and aggregation criteria; see the dedicated page for details.

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  • Product types
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    Antibodies (510)
  • Target
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    IFNB1/IFN-beta (1)
    Envelope protein E (7)
    Alpha-toxin/hly (1)
    botA/BoNT (2)
    IL2 (1)
    HGF (1)
    CSF2/GM-CSF (1)
    IGF1 (2)
    GREM1/DAND2 (1)
    CFD (1)
    sLea/CA19-9 (1)
    shiga toxin type 1B/stx1B (1)
    IL5 (1)
    NGF/Beta-NGF (2)
    Glycoprotein G (6)
    IL1B/IL1F2 (1)
    CSF1/M-CSF (1)
    IFNAR1 (1)
    VWF (1)
    STAT3 (1)
    GPC (1)
    GDF11/BMP11 (1)
    CD254/RANKL/TNFSF11 (1)
    VSIG4/CRIg (1)
    IFNG/IFN-gamma (2)
    BDNF (1)
    gE/Envelope glycoprotein E (1)
    HA/Hemagglutinin (7)
    ApoC3 (1)
    cyaA/Cyclolysin (2)
    Capsid protein (2)
    CCL8/MCP-2 (1)
    GFRAL (1)
    NS1/gp68/gp70 (6)
    IL6 (2)
    APOE4 (1)
    APP/Amyloid beta (1)
    HTRA1/PRSS11 (1)
    IL1A/IL1F1 (1)
    Spike glycoprotein 2 (5)
    ROBO2 (1)
    THPO/Thrombopoietin (1)
    APOE (1)
    CD228/MELTF (1)
    TNFa/TNF-alpha (2)
    IGF2 (1)
    ADAMTS4 (4)
    RBD (S6P trimer) (3)
    F2/Prothrombin/PIVKA-II (1)
    CD268/TNFRSF13C (2)
    PDGFD (1)
    CD279/PD-1 (8)
    IL23A (1)
    TPSAB1/Tryptase-1 (1)
    CD274/PD-L1 & CD28 (1)
    aPC/Activated protein C (3)
    IL21 (1)
    CD152/CTLA4 & CD134/OX40 (1)
    Pre-F/Fusion glycoprotein F0 (2)
    CX3CL1/Fractalkine (1)
    EGFR/ERBB1 & CD3E (1)
    IFNA1/Interferon alpha-D (1)
    CCL17/TARC (1)
    CD274/PD-L1 (5)
    ProteinUL128 & UL131A (1)
    Fusion glycoprotein (4)
    BMP4 (1)
    HHRF3/US28 (1)
    Procapsid [(VP0/1/3) 5] 12 (2)
    Heparanase (1)
    CD16a/FCGR3A (3)
    APOE3/4 (1)
    NP/Nucleoprotein (3)
    VEGFA (1)
    Spike glycoprotein (1)
    Protein prM/prM (3)
    S2/Spike protein S2' (1)
    BMP2 (1)
    RBD (Omicron/JN.1) (2)
    TERM2 (1)
    PDGFB (1)
    Prefusion Protein (2)
    CSF3/G-CSF (1)
    Toxin A/tcdA (1)
    BMP6 (1)
    pro-MSTN/GDF8 (1)
    NA/Neuraminidase (1)
    CD132/IL2RG (1)
    TGFB2/TGF-beta-2 (1)
    IFN α2/IFNA2 (1)
    CCL24/Eotaxin-2/MPIF-2 (1)
    Capsid protein VP25 (1)
    gH/gL Complexes (2)
    TCRαβ/alpha-beta TCR (1)
    SOST (1)
    IL36RN/IL-1F5/IL-36Ra (1)
    KLKB1/KLK3 (1)
    env/Envpolyprotein (1)
    CXCL10/IP-10 (1)
    CD52 (1)
    CD295/LEPR (1)
    RBD (13)
    EGFRvIII & CD3E (1)
    NS1 (1)
    CXCL12/SDF-1 (1)
    IL20 (1)
    HSP90 (1)
    GPA33 (1)
    CD20/MS4A1 & CD3E (1)
    Intermediate capsid protein VP6 (1)
    Flt3 ligand/FLT3LG (1)
    GP1 glycoprotein (2)
    ROR1/NTRKR1 (1)
    F/Fusion glycoprotein F0 (8)
    ADAMTS5 (2)
    TGFA/TGF-alpha (1)
    CNR1/CB1 (3)
    HBEGF (1)
    APOE2/3/4 (1)
    GDF2/BMP9 (1)
    mature virion in complex (5)
    gH/Envelope glycoprotein H (2)
    NS1/Non-structural protein 1 (1)
    BTN3A (1)
    TGFB1 (2)
    LRP6 (1)
    BMP10 (1)
    env/Env polyprotein (4)
    EGFRvIII-specific/EGFR variant III (2)
    CD49d/ITGA4 (1)
    Protease/PR (1)
    CD20/MS4A1 (1)
    CD110/TPOR (2)
    S1 N-terminal domain/S1-NTD (1)
    VLP (1)
    CA9 (1)
    FOLH1/PSMA (1)
    gD/Envelope glycoprotein D (2)
    F12/Coagulationfactor XII (1)
    Fluorescein & CD274/PD-L1 (1)
    CCL5/RANTES (1)
    RSPO3 (1)
    Fusion glycoprotein F0 (4)
    DPEP3 (1)
    GIPR/GIP-R (2)
    gH/UL75 (1)
    CD172a/SIRPA (3)
    FAP & CD3E (1)
    Glycoprotein C/Gc (2)
    MUC16/CA-125 (1)
    CD340/ERBB2 & CD3E (2)
    CD279/PD-1 & CD274/PD-L1 (1)
    gB/Envelope glycoprotein B (8)
    MSLN/Mesothelin (1)
    TSG101 (2)
    ERBB3/HER3 (1)
    CD4 (1)
    CD115/CSF1R (1)
    Blood group Hantigen/Globo H (3)
    EPO (1)
    ATTR/Transthyretin amyloidosis (4)
    Mature virion in Complex [(VP0/1/3)5]12 (2)
    CDH17/Cadherin-17 (1)
    CD335/NCR1/NKp46 (1)
    L1/Major capsid protein L1 (2)
    G/Major surface glycoprotein G (2)
    Fusion glycoprotein/F Trimer (1)
    CD137/4-1BB (2)
    CD3E (2)
    PF45/48 (2)
    IL6R (1)
    L2/Minor capsid protein L2 (2)
    APCS/PTX2 (1)
    gp125 (1)
    CXCL11/I-TAC (1)
    CD99 (1)
    OSM/Oncostatin-M (1)
    S/Spike glycoprotein (1)
    ADM/Adrenomedullin (1)
    Fluorescein & CD47/MER6 (1)
    VTCN1/B7-H4 (1)
    CD73/NT5E (2)
    CD40/TNFRSF5 (1)
    TRP-1 & CD134/OX40 (1)
    CXCL4/PF4 (1)
    CCL3/MIP-1-alpha (1)
    CD19 & CD3E (1)
    CD114/G-CSFR (1)
    CCL11/Eotaxin (1)
    ENT2/SLC29A2 (1)
    CD152/CTLA4 (2)
    ANGPTL3 (1)
    IL17A (4)
    Capsid protein VP1/VP3/VP4 (2)
    Tityustoxin VII/Toxin VII/Ts7 (1)
    CD279/PD-1 & CD47/MER6 (1)
    CD283/TLR3 (2)
    MASP2 (1)
    S2 Protein (1)
    lukF (1)
    CD8a/Lyt2 (1)
    CSPG4/HMW-MAA/MCSP (1)
    PAUF (1)
    Major surface glycoprotein G (3)
    GPRC5D (1)
    TREM1 & CD46 (1)
    CD16/CD32 (1)
    shiga toxin type 2A/stx2A (1)
    SOD1 (1)
    CCL1/I-309 (1)
    IL31RA (1)
    AFP/Alpha-fetoprotein (1)
    CTGF/CCN2 (1)
    RAGE/AGER (3)
    Neuraminidase/NA (3)
    PTP4A1/PRL1 (1)
    FCGRT/FCRN (1)
    CD314/KLRK1 & CD3E (1)
    S-HBsAg/SHB (1)
    C1S (1)
    VSIR/VISTA & CD274/PD-L1 (1)
    FedF (1)
    IL12B/IL-12 p40 (1)
    TIGIT (3)
    ADGRE1/F4/80 & CD3E (1)
    gp120/Glycoprotein 120 (1)
    CD9 (1)
    STEAP1 (1)
    TNFSF9/4-1BBL (2)
    CD274/PD-L1 & CD3E (1)
    VP1/Coatprotein VP1 (2)
    CD307e/FCRL5 (1)
    PRLR (1)
    IL11RA (2)
    L3/CP-H/Protein II (1)
    ANGPTL4 (2)
    shiga toxin type 2/stx2B (1)
    GP/Glycoprotein (5)
    CD122/IL2RB (1)
    CD340/ERBB2 (1)
    PDGFC (1)
    Major capsid protein L1 (3)
    LGR5/GPR49 (1)
    CD276/B7-H3 & CD3E (1)
    F8/Coagulation factor VIII (7)
    wlaB/pglK (1)
    IL8/CXCL8 (1)
    CLDN3/Claudin-3 (1)
    LRRC15/LIB (1)
    FGF21 (1)
    gB/UL27 (1)
    CD37/TSPAN26 (1)
    CCL14/NCC-2 (1)
    IL10 (1)
    Outer capsid protein VP4 (2)
    IL18/IL1F4 (1)
    IL17F (1)
    GDF15/MIC1 (1)
    F9/Factor IX (1)
    CD200 & CD47/MER6 (1)
    Toxin B/tcdB (1)
    TGM2 (1)
    Galectin-3/Gal-3 (1)
    TSLP (1)
    SAA (2)
    P domain (1)
    CXCL1/NAP-3/GRO-alpha (1)
    CCL2/MCP-1 (1)
    EPOR (3)
    MUC5AC (1)
    CD274/PD-L1 & CD47/MER6 (1)
    CDH11 (1)
    CD120b/TNFR2 (1)
    BAG3 (1)
    SNCA/Alpha-synuclein (5)
    HLA-A*11:01 (1)
    ARG1/Arginase-1 (2)
    OPN/SPP1 (1)
    Fc Block (1)
    LTA/TNF-beta (1)
    LAMP5 (1)
    PTP4A3/PRL3 (1)
    SSEA4 (4)
    gp140/Env Trimer (2)
    CD79B & CD3E (1)
    RBP2b (1)
    IL31 (4)
    TREML1/TLT1 (1)
    ERVW-1/HERV-W-Env (1)
    SFRP1 (1)
    CD274/PD-L1 & CD134/OX40 (1)
    CXCL9/MIG (1)
    ACE2 (2)
    IL13 (1)
    Fluorescein & CD3E (1)
    FAP/FAPalpha (1)
    CD152/CTLA4 & CD274/PD-L1 (1)
    Pvs25 (1)
    TRP-1 & CD47/MER6 (1)
    CDH1/CDH11 (1)
    entB/SEB (1)
    Capsid protein VP2 (1)
    TRP-1 & CD3e (1)
    iga/IgA1 protease (1)
    IL22 (1)
    WNT2 (2)
    gB/BALF4 (2)
    E1 & E2 (gp35 & gp70) (3)
    EGFL7 (1)
    IL11 (2)
    Capsid protein VP1 (2)
    HBsAg (5)
    TSHR/LGR3 (2)
    IL9 (1)
    TIGIT & CD274/PD-L1 (1)
    Outer capsid glycoprotein VP7 (1)
    ACVRL1/ALK-1 & VEGFA (1)
    PSCA (1)
    CD198/CCR8 (2)
    GP/Envelopment polyprotein (1)
  • Species
    0 selected
    Hepatitis C Virus (HCV) (9)
    Bundibugyo ebolavirus (BDBV) (1)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (21)
    Monkey (1)
    Mouse (65)
    Human herpesvirus 1 (HSV-1/HHV-1) (5)
    Rabbit (2)
    Suid alphaherpesvirus 1 (SuHV-1/PRV) (3)
    Seoul virus (SEOV) (2)
    Human metapneumovirus (2)
    Rat (1)
    Human metapneumovirus (HMPV) (5)
    Human cytomegalovirus (HCMV/HHV-5) (7)
    Enterovirus 71 (EV71) (4)
    Tai Forest ebolavirus (TAFV) (1)
    Ebola virus (EBOV) (1)
    Human astrovirus-8 (HAtVs) (1)
    Varicella-zoster virus (VZV/HHV-3) (4)
    Andes virus (ANDV) (2)
    Dog (11)
    Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)
    Zika virus (ZIKV) (2)
    Candida albicans (1)
    Machupo virus (MACV) (1)
    Human respiratory syncytial virus (HRSV) (14)
    Coxsackievirus A16 (CVA16) (2)
    Human parvovirus B19 (HPV B19) (3)
    Hendra virus (HeV) (2)
    Sudan ebolavirus (SEBOV) (1)
    Chikungunya virus (CHIKV) (1)
    Nipah virus (NiV) (13)
    Sin Nombre virus (SNV) (2)
    General (3)
    Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)
    Human papillomavirus 6 (HPV6) (1)
    Bovine respiratory syncytial virus (BRSV) (2)
    Plasmodium falciparum (2)
    Enterovirus D68 (EV-D68) (2)
    Brazilian scorpion (1)
    Human papillomavirus 16 (HPV16) (2)
    Staphylococcus aureus (3)
    Hepatitis B virus genotype A (HBV-A) (6)
    E. coli (4)
    Japanese encephalitis virus (JEV) (1)
    Human immunodeficiency virus 1 (HIV-1) (10)
    Human adenovirus 3 (HAdV-3) (1)
    Zaire ebolavirus (ZEBOV) (6)
    Human papillomavirus 58 (HPV58) (3)
    Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)
    Campylobacter jejuni subsp. (1)
    Dengue virus type 1 (DENV-1) (1)
    Rotavirus (RV) (1)
    Hantaan virus (HTNV) (2)
    Clostridioides difficile (2)
    Hepatitis E virus/HEV (1)
    Influenza B virus (Flu B) (1)
    Cat (1)
    Coxsackievirus B1 (CBV1) (3)
    Dengue virus type 3 (DENV-3) (1)
    Human endogenous retroviruses W (HERV-W) (1)
    Human papillomavirus 59 (HPV59) (1)
    Human (224)
    Plasmodium vivax (2)
    Human hepatitis A virus (HHAV) (1)
    Puumala virus (PUUV) (2)
    Streptococcus pneumoniae (1)
    Epstein-Barr virus (EBV/HHV-4) (2)
    Poliovirus type 1 (PV1) (2)
    Rotavirus A (RV-A) (4)
    Orthohantavirus puumalaense (PUUV) (1)
    Dengue virus type 2 (DENV-2) (9)
    Clostridium botulinum (2)
    Reston ebolavirus (REBOV) (1)
    Junin mammarenavirus (JUNV) (1)
    Dengue virus type 4 (DENV-4) (1)
    Lassa virus (LASV) (1)
    Dobrava-Belgrade virus (DOBV) (2)
    Influenza A virus (Flu A) (9)
    Bordetella pertussis (2)
    Porcine circovirus 2 (PCV2) (2)
  • Applications
    0 selected
    Nneutralization (1)
    RIA (1)
    FACS (2)
    FCM (77)
    IHC-F (3)
    in vivo study (4)
    ICC (1)
    in vivo blocking of PD-1/PD-L signaling (2)
    Functional assay (2)
    FuncS (55)
    WB (22)
    in vivo (1)
    T cell stimulation (Reported) (1)
    Research in vivo (2)
    IF (8)
    in vivo CD4+ T cell depletion (1)
    IHC (6)
    SPR (18)
    T cell depletion (Reported) (1)
    IP (5)
    Cell Deplete (1)
    ELISA (424)
    Antagonist (1)
    Neutralization (388)
     ELISA (1)
    DB (2)
    in vivo PD-L1 blockade (3)
    in vivo research (1)
    Blocking (41)
    Agonist (8)
    in vitro PD-L1 blockade (3)
    Stimulatory (1)
  • Reactivity
    0 selected
    Influenza B virus (1)
    Chikungunya virus (1)
    Human (16)
    Coxsackievirus B1 (CVB1) (3)
    Puumala virus (1)
    Mouse (12)
  • Host species
    0 selected
    Mouse (161)
    Alpaca (5)
    Dog (8)
    Human (319)
    Rat (11)
    Hamster (1)
    Cat (1)
  • Clonality
    0 selected
    Monoclonal (510)
  • Conjugate
    0 selected
    Unconjugated (510)

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