Please ensure Javascript is enabled for purposes of website accessibility
Contact us Contact Us
EN
Home > Products > Antibodies > XtenNano®Nanobodies

Nanobodies (VHH / Single-Domain Antibodies)

abinScience nanobodies (VHH, ~15 kDa) deliver high affinity and exceptional stability for blocking, imaging and capture workflows. Offered as monovalent VHH, bivalent/bispecific constructs and VHH-Fc fusions, with options for humanization, albumin-binding half-life extension, and conjugates (biotin/HRP/fluor). Produced in E. coli, HEK293 or CHO with lot-specific CoAs for purity, monomer %, endotoxin and activity. RUO

Why Researchers Choose abinScience

High-Affinity Panels Epitope & competition notes
Flexible Formats Monovalent, bivalent, VHH-Fc, albumin-binding
Multiple Hosts E. coli, HEK, CHO; low endotoxin
Ready Conjugates Biotin, HRP, Alexa Fluor 488/594/647
Lot-Specific QC Purity, monomer %, endotoxin, activity

Shop by Format

Shop by Application

Selection Guide

  1. Use Case: Blocking (choose high-affinity, epitope-defined VHH) vs. imaging (small monovalent VHH or fluor-labeled).
  2. Valency/Fc: VHH-Fc or bivalent VHH increases avidity and half-life; monovalent reduces steric effects and improves penetration.
  3. Expression Host: E. coli for rapid screens; HEK/CHO for Fc fusions and glyco-dependent stability.
  4. Conjugation: Biotin/HRP for ELISA; Alexa 488/647 for IF/live-cell; keep free VHH for neutralization/MoA assays.
  5. Endotoxin & Monomer %: Check lot CoA (SEC-HPLC) for aggregation and endotoxin per sensitive cell assays.

Applications

Receptor/ligand blocking and virus neutralization studies
Live-cell tracing and super-resolution IF with minimal steric hindrance
Affinity capture, enrichment and immunopurification
SPR/BLI kinetics and biosensor construction

Documents & QC

CoA with purity, monomer %, endotoxin and activity method
SEC-HPLC/SDS-PAGE images; storage & reconstitution guidance

FAQs

What is a nanobody (VHH)?

A single-domain antibody derived from camelid heavy-chain-only antibodies; ~15 kDa, highly stable/soluble with excellent tissue penetration.

When should I choose VHH-Fc or bivalent formats?

Use VHH-Fc/bivalent for higher apparent affinity/half-life and plate/cell capture; choose monovalent for steric-sensitive epitopes or intracellular use.

Are these humanized?

Selected SKUs offer humanized frameworks or Fc fusions; see product page for sequence origin and species compatibility.

RUO disclaimer

All products are for Research Use Only and not for diagnostic or therapeutic procedures.

Options+
Options
Confirm
  • Product types
    0 selected
    Antibodies (949)
    Research Biosimilar (19)
  • Expression system
    0 selected
    Mammalian Cells (20)
  • Target
    0 selected
    ISG15 (2)
    6*His Tag (1)
    Albumin/HSA (4)
    Phl p 4 (1)
    PSA/KLK3 (1)
    CD158a/KIR2DL1 (1)
    GCN4/AAS3 (1)
    ctxB/Cholera Toxin Subunit B (2)
    BLM (3)
    IRSp53/BAIAP2 (1)
    CD268/TNFRSF13C/BAFFR (1)
    PAD4 (1)
    TTYH2 (1)
    CD184/CXCR4 (1)
    AZT/Aztreonam (2)
    PLAU (1)
    GP/Glycoprotein (1)
    AKT1 (2)
    NAP1L1 (1)
    ROR1/NTRKR1 (5)
    GSN/Gelsolin (4)
    EPEATag (2)
    FOLR1 (1)
    2 (2)
    NP/Nucleoprotein (15)
    GPC3/Glypican3 (1)
    CD33 (1)
    CD14 (1)
    SLC10A1 (3)
    DRD2 (6)
    HTT (3)
    GPR68 (1)
    CD163 (1)
    CD331/FGFR1 (1)
    CD5/Ly-1 (3)
    CD370/CLEC9A (7)
    CCL2/MCP-1 (1)
    RECQL5 (9)
    CD114/CSF3R (1)
    GFAP (2)
    MLANA (1)
    NOTCH1 (1)
    CD1d (1)
    CD11b/ITGAM (6)
    PGF/PLGF (1)
    CD309/VEGFR-2 (1)
    CX3CR1 (2)
    Envelopeglycoprotein E2/gp55 (3)
    Allergen Pis v 2/11S globulin (1)
    DKK1 (2)
    HBEGF (1)
    AURKA (1)
    EPHB6 (1)
    CD28 (1)
    Microcystin-LR (2)
    TG/Thyroglobulin (2)
    GABRB3 (1)
    CD339/JAG1 (1)
    Genome polyprotein (1)
    CRP (2)
    LMO2 (2)
    ompA (2)
    PIGR (1)
    IL17F (1)
    C5/Complement C5 (1)
    CD156b/ADAM17 (1)
    Fab Fragment (1)
    ANGPT4 (1)
    AMY2 (1)
    HTR2A (1)
    EPOR (2)
    Glycoprotein G1 (1)
    CD123/IL-3Rα (1)
    4-D (2)
    GST 26 (1)
    CD152/CTLA4 (8)
    VIM/Vimentin (1)
    SYNJ1 (2)
    CD47/MER6 (6)
    TUFM (1)
    SP140 (1)
    tetX/Tetanus toxin (1)
    GRM2 (1)
    CD206/MRC1 (6)
    GABRA1 (1)
    CD223/LAG3 (3)
    VEGF/ANG-2 (1)
    CDw210b/IL10RB (10)
    DCX (2)
    ADAM9 (1)
    gD/Envelope glycoprotein D (1)
    Adiponectin/ADPN (1)
    BIRC5 (1)
    Capsid protein (6)
    CCT5 (1)
    entB/SEB (1)
    CD275/ICOSLG (1)
    CHRM2 (2)
    CD45/PTPRC (8)
    Nup54 (1)
    CD167b/DDR2 (1)
    CAT/Catalase (1)
    InlB/Internalin B (2)
    ACTB/β-actin (1)
    BACE2 (5)
    CDKN2A/p16INK4a (1)
    PPIA (1)
    GPHN/Gephyrin (1)
    KCNA3 (1)
    gD (2)
    SOD1 (1)
    CD137/4-1BB (1)
    lgM (1)
    BC2 tag (1)
    RNase A (1)
    SOST (1)
    Alpha-cobratoxin (1)
    PTK7 (1)
    B2M/β2M (2)
    Shiga toxin 2 subunit B/stx2eB (2)
    Fusion Protein (1)
    RHOB (2)
    TRPM4/LTRPC4 (1)
    dsRed (1)
    porM (4)
    TK1 (1)
    Albumin/HSA & IFNAR1/IFNAR2 (1)
    CDH17/Cadherin-17 (2)
    CCL3/MIP-1-alpha (2)
    A2AR/ADORA2A (1)
    CASP3/Caspase-3 (3)
    CD282/TLR2 (2)
    CXCL12/SDF-1 (1)
    GAL-7/Galectin-7 (1)
    CD16b/FCGR3B (3)
    Glycoprotein E2 (1)
    S/Spike glycoprotein (2)
    ANGPT2/ANG-2 (1)
    CD20/MS4A1 (1)
    Intact VWF (1)
    MMP12 (1)
    IL12RB2 (1)
    CD221/IGF1R (1)
    CD279/PD-1 (1)
    Capsid protein VP1 (1)
    CD8A (1)
    mAb-1E7 (1)
    botA/BoNT (3)
    SNCA/Alpha-synuclein (1)
    ANGPT1 (1)
    ASIC1 (1)
    G-quadruplex DNA (1)
    GPC3/Glypican 3 (1)
    CD85a/LILRB3 (1)
    AaH II/Neurotoxin II (4)
    F0 (1)
    FOLH1/PSMA (1)
    M1R (1)
    HIF1A (2)
    PASM (1)
    LYZ (4)
    Phl p 6 (2)
    CFP/Properdin (2)
    CAVIN1 (1)
    G protein (1)
    CD156a/ADAM8 (1)
    Kappa Chain (5)
    E6/Protein E6 (4)
    PTH1R (2)
    CD252/TNFSF4/OX40L (1)
    TRPC3 (1)
    HHRF3/US28 (5)
    CD18/ITGB2 (1)
    ADRB2 (3)
    CTNNB1 (4)
    TACSTD2/TROP2 (1)
    babA2 (1)
    CD31/PECAM1 (2)
    CD212/IL12RB1 (2)
    LYZ/LysozymeC (1)
    LRP6 (2)
    ureB/Urease subunit beta (1)
    CXCL11/I-TAC (8)
    CASR (1)
    C4b/Complement C4b (2)
    GPR183 (1)
    CD7 (1)
    CD197/CCR7 (1)
    RNA-directed RNA polymerase L/ProteinL (1)
    MAGEB1 (3)
    CD337/NCR3/NKp30 (2)
    LYZ/Lysozyme C (7)
    Betv1/Allergen Bet v 1-A (1)
    CD3E & DLL3 & ALB (2)
    LSP1 (1)
    CD64/FCGR1A (2)
    Complement C6 (1)
    FURIN (2)
    CADM3/NECL-1/TSLL1 (5)
    SLC5A8 (6)
    IgE/IGHE (1)
    CD4 (1)
    CD269/BCMA (1)
    AGTR1 (2)
    CD29/ITGB1 (1)
    F/Fusion glycoprotein F0 (10)
    EGFR/ERBB1 (8)
    CD11a/ITGAL (1)
    SLC4A7 (1)
    G9 (2)
    IgM (1)
    TNFa/TNF-alpha (4)
    CD369/CLEC7A (1)
    FZD3 (2)
    OLR1/LOX-1 (1)
    TREM2 (4)
    CD9 (2)
    CD202b/TEK/TIE-2 (1)
    CD182/CXCR2 (1)
    stxB/SLT-1b/VT1 (2)
    MLPH (1)
    gB (2)
    BAX (2)
    CD273/PD-L2/PDCD1LG2 (1)
    Galectin-1 (1)
    GBA (1)
    Lambda light chain (1)
    APOE (1)
    ASC/TMS1/PYCARD (2)
    Envelope protein E (1)
    MUC16/CA-125 (1)
    GP42/Glycoprotein 42 (2)
    RNA polymerase complex (2)
    Nucleoporin Nup58/54/62 (1)
    CD13/ANPEP/APN (11)
    Albumin/Alb (1)
    EPHX2 (1)
    CD3E (3)
    CD135/FLT3 (1)
    CD32/FcgR2 (1)
    H2AX (2)
    CD132/IL2RG (1)
    ADAMTS13-cleaved VWF (1)
    CD112/Nectin-2/PVRL2 (2)
    CD122/IL2RB (1)
    nef/F-protein/Negative factor (1)
    GRM5 (2)
    ADRB1 (5)
    BCL2 (2)
    BoNT/B (5)
    OPRK1 (1)
    Nucleoprotein (1)
    Spike glycoprotein (87)
    mCherry (3)
    ERBB3/HER3 (1)
    IL6 (2)
    HRH2 (1)
    ALFA tag (1)
    AX/Amoxicillin (3)
    CD332/FGFR2 (1)
    Protein P (2)
    TP53/p53 (2)
    BACE1 (1)
    CD106/VCAM1 (2)
    short-chain α-neurotoxin (1)
    CD209 (1)
    ADAMTS5 (2)
    Enhanced GFP (1)
    CD70 (1)
    CD120a/TNFR1 (4)
    SV2A (1)
    Nav1.4 (2)
    IFNG/IFN-gamma (1)
    IL17RB (1)
    SERPINE1/PAI-1 (5)
    CNR1/CB1 (4)
    GFP (5)
    AaH I/Neurotoxin I (1)
    APP/Amyloid beta (1)
    F (1)
    CD40/TNFRSF5 (1)
    ADAM12 (2)
    G9&A16 complex (2)
    IL12B/IL-12 p40 (1)
    wlaB/pglK (1)
    ARC (4)
    VHH (5)
    MET/HGFR (1)
    ureC/glmM (1)
    RBD (4)
    Ricin (24)
    GST (1)
    CD156c/ADAM10 (1)
    rev/ART/TRS (1)
    KRT19/CK19 (1)
    Gag polyprotein (3)
    VSIG4/CRIg (8)
    CD217/IL17RA (1)
    APLNR/APJ (2)
    H2-Ab1/MHCII (6)
    CRMP1 (1)
    nup54.S/Nup54 (1)
    CD89/FCAR (1)
    CD72 (1)
    PCSK9 (2)
    higB-2 (7)
    VEGFA (2)
    PA/pagA/PA-83 (1)
    p-γ-H2AX (1)
    F11/Coagulation factor XI (1)
    CGA/CG-alpha (1)
    NSP2 (1)
    NadA/Neisseria adhesin A (2)
    LGR4 (1)
    CD230/PRNP (2)
    E2 (1)
    xcpQ (1)
    C3/Complement C3 (2)
    CD49c/ITGA3 (1)
    CD66c/CEACAM6 (2)
    CD38/ADPRC 1 (5)
    CD71/TFRC (2)
    CD16a/FCGR3A (1)
    MC4R (2)
    RNA-directed RNA polymerase/NSP9 (1)
    MAPT/Tau (4)
    MERS-CoV RBD (1)
    B2M/β2-MG (1)
    CFH (1)
    CD3E & Mesothelin & ALB (1)
    ACKR1/CD234 (1)
    ANGPTL4 (1)
    Nav1.5 (2)
    CD262/TRAIL-R2/DR5 (3)
    CD340/ERBB2 (5)
    C3b/Complement C3b (1)
    IL23A (1)
    NCL (1)
    E7/ProteinE7 (1)
    OPRM1/μOR (1)
    IgG1 Fc Fragment (1)
    GAK (1)
    CCL5/RANTES (1)
    MAPK13 (1)
    PTCH1 (3)
    Capsid protein VP3 (1)
    gp120/Glycoprotein 120 (6)
    KLB/Beta-klotho (2)
    PLAC1 (3)
    CLDN18.2 (1)
    CD274/PD-L1 (12)
    CD19 (2)
    DPP6 (1)
    CD254/RANKL/TNFSF11 (1)
    babA (1)
    CD126/IL6R (1)
    5HT3/HTR3A (1)
    MMP13 (1)
    CPB2/TAFI (5)
    Vif/SOR protein (1)
    CD16/FcgR3 (1)
    CALCA/Calcitonin (1)
    DLL3 (1)
    MSLN/Mesothelin (2)
    VWF (4)
    GP2 (1)
    AKT3 (1)
    stxB2/SLT-2b/VT2 (1)
    GP6/GPVI (1)
    Tenuazonic acid (3)
    Bet v 1/Allergen Bet v I-A (3)
    CTGF/CCN2 (1)
    CFTR (7)
    NOTCH2 (1)
    TRIM28 (1)
    PTH (1)
    DLL4 (1)
    MoonTag (1)
    VRG4 (2)
    E7/Protein E7 (4)
    CD154/CD40L (1)
    NOTCH3 (1)
    botA/BOTOX (20)
    Fusion glycoprotein F0 (1)
    A29L (16)
    COL1A1 (1)
    CXCR7/ACKR3 (1)
    TNFα (2)
    CD136/MST1R (1)
    FOS (1)
    Mal f 1/Allergen Pit o 1 (16)
    botA (4)
    RAGE-1/MOK (2)
    CEP164 (2)
    TMPRSS2 (1)
    CD284/TLR4 (1)
    SLC5A1 (1)
    lexA/LexA repressor (1)
    CD66e/CEA (4)
    CD276/B7-H3 (1)
    ATP7B (3)
    CD124/IL4R (1)
    Toxin A/tcdA (2)
    AFB1/Aflatoxin B1 (1)
    trxA/Thioredoxin (1)
    CD366/TIM-3 (2)
    MDM4 (1)
    CD326/EPCAM (1)
    STAT3 (1)
    PSIP1 (1)
    WFDC2/HE4 (1)
    CD49e/ITGA5 (1)
    Toxin B/tcdB (2)
    IL23R (3)
    CD86/B7-2 (2)
    MTX/Methotrexate (2)
    CD32b/FCGR2B (1)
    Trastuzumab (1)
  • Species
    0 selected
    Poliovirus type 1 (PV1) (1)
    Human cytomegalovirus (HCMV/HHV-5) (1)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (1)
    Human respiratory syncytial virus (HRSV) (3)
    Campylobacter jejuni subsp. (1)
    Human (22)
    Human immunodeficiency virus 1 (HIV-1) (1)
    Mouse (3)
  • Applications
    0 selected
    Bioactivity: FACS (19)
    RIA (16)
    BIF (7)
    in vivo neutralization (1)
    IHC (17)
    Functional assay (19)
    Cyro-EM (1)
    IP (38)
    DB (5)
    Research in vivo (19)
    X-ray Crystallography (1)
    EMSA (1)
    FCM (201)
    BLI (1)
    IF (79)
    Isotype Control (5)
    FuncS (13)
    ELISA (902)
    Neutralization (42)
    Agonist (1)
    WB (92)
    Inhibition (3)
    SPR (113)
    Blocking (16)
  • Reactivity
    0 selected
    Microcystis aeruginosa (2)
    Hepatitis C Virus (HCV) (1)
    Human respiratory syncytial virus (HRSV) (6)
    HSV-1 (4)
    Escherichia coli (2)
    Hendra virus (1)
    Influenza A virus (Flu A) (6)
    Oropouche virus (1)
    Blood fluke (1)
    Clostridium tetani (1)
    Norwalk virus (1)
    Human herpesvirus 1 (HSV-1/HHV-1) (1)
    Norwalk virus (NV) (5)
    Staphylococcus aureus (1)
    Listeria monocytogenes (2)
    HSV-2 (4)
    Bovine (1)
    Naja kaouthia (1)
    Nipah virus (1)
    Discosoma sp. LW-2004 (1)
    Porphyromonas gingivalis (4)
    Classical swine fever virus (CSFV) (2)
    Severe acute respiratory syndrome coronavirus (SARS-CoV) (2)
    Bacillus cereus (1)
    Human (494)
    Chicken (7)
    Helicobacter pylori (4)
    Human cytomegalovirus (HCMV/HHV-5) (4)
    Bacteriophage H19B (2)
    Mouse (65)
    Zika Virus (1)
    Rat (3)
    Epstein-Barr virus (EBV/HHV-4) (2)
    Sudan ebolavirus (SEBOV) (2)
    Junin mammarenavirus (1)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (93)
    Parainfluenza virus 5 (PIV5) (2)
    Human immunodeficiency virus 1 (HIV-1) (11)
    Water jellyfish (6)
    Sahara scorpion (5)
    HPIV-3 (1)
    Cynomolgus monkey (1)
    Vaccinia virus (VACV) (4)
    Castor bean (24)
    Schistosoma japonicum (Blood fluke) (1)
    African clawed frog (3)
    Bacillus anthracis (2)
    Chikungunya virus (1)
    Neisseria meningitidis (2)
    Vesicular stomatitis Indiana virus (VSIV) (3)
    Pseudomonas aeruginosa (1)
    Porcine reproductive and respiratory syndrome virus (PRRSV) (2)
    MERS-CoV (1)
    Poliovirus type 1 (PV1) (1)
    Wild turkey (1)
    Bacteriophage 933W (1)
    Alternaria species. (3)
    European white birch (4)
    Candida albicans (2)
    Human papillomavirus 16 (HPV16) (9)
    Clostridium botulinum (32)
    Nipah virus (NiV) (1)
    Monkeypox virus (MPXV) (16)
    Canis lupus familiaris (Dog) (2)
    Malassezia furfur (16)
    Anaplasma marginale (2)
    Cynomolgus (8)
    Clostridioides difficile (4)
    E. coli (4)
    Human metapneumovirus (HMPV) (2)
    Phleum pratense (Common timothy) (3)
    Baker's yeast (1)
    Vibrio cholerae (9)
    Zaire ebolavirus (ZEBOV) (1)
    General (13)
    Vesicular stomatitis Indiana virus (3)
    Pig (7)
    Bovine viral diarrhea virus (BVDV) (3)
    Pistachio (1)
  • Host species
    0 selected
    Mouse (123)
    Human (128)
    Alpaca (705)
    Rat (5)
  • Clonality
    0 selected
    Monoclonal (968)
  • Conjugate
    0 selected
    FITC (21)
    APC (20)
    PerCP (20)
    PE (21)
    Unconjugated (885)

Quick access

Contact Us

  • +86-027-65523339

  • info@abinscience.com

  • Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China

Copyright © 2025 abinScience. All Rights Reserved. All Products are for Research Use Only