When to use VHH-Fc or bivalent formats?

Use VHH-Fc/bivalent for higher avidity and half-life; monovalent for steric-sensitive epitopes or intracellular applications.

Are your nanobodies humanized?

Some SKUs are humanized or provided as human Fc fusions. Check each product page for framework origin and compatibility.

All products are for Research Use Only (RUO) and not for diagnostic or therapeutic procedures.

Nanobodies (VHH) | Single-Domain, High Affinity

Q: What is a nanobody (VHH)?

A single-domain antibody (~15 kDa) from camelid heavy-chain-only Ig. It is highly stable/soluble with strong tissue penetration.

Home > Products > Antibodies > XtenNano®Nanobodies

abinScience nanobodies (VHH, ~15 kDa) deliver high affinity and exceptional stability for blocking, imaging and capture workflows. Offered as monovalent VHH, bivalent/bispecific constructs and VHH-Fc fusions, with options for humanization, albumin-binding half-life extension, and conjugates (biotin/HRP/fluor). Produced in E. coli, HEK293 or CHO with lot-specific CoAs for purity, monomer %, endotoxin and activity. RUO

Why Researchers Choose abinScience

High-Affinity Panels Epitope & competition notes

Flexible Formats Monovalent, bivalent, VHH-Fc, albumin-binding

Multiple Hosts E. coli, HEK, CHO; low endotoxin

Ready Conjugates Biotin, HRP, Alexa Fluor 488/594/647

Lot-Specific QC Purity, monomer %, endotoxin, activity

Shop by Format

Shop by Application

Selection Guide

Use Case: Blocking (choose high-affinity, epitope-defined VHH) vs. imaging (small monovalent VHH or fluor-labeled).
Valency/Fc: VHH-Fc or bivalent VHH increases avidity and half-life; monovalent reduces steric effects and improves penetration.
Expression Host: E. coli for rapid screens; HEK/CHO for Fc fusions and glyco-dependent stability.
Conjugation: Biotin/HRP for ELISA; Alexa 488/647 for IF/live-cell; keep free VHH for neutralization/MoA assays.
Endotoxin & Monomer %: Check lot CoA (SEC-HPLC) for aggregation and endotoxin per sensitive cell assays.

Applications

Receptor/ligand blocking and virus neutralization studies

Live-cell tracing and super-resolution IF with minimal steric hindrance

Affinity capture, enrichment and immunopurification

SPR/BLI kinetics and biosensor construction

Documents & QC

CoA with purity, monomer %, endotoxin and activity method

SEC-HPLC/SDS-PAGE images; storage & reconstitution guidance

FAQs

What is a nanobody (VHH)?

A single-domain antibody derived from camelid heavy-chain-only antibodies; ~15 kDa, highly stable/soluble with excellent tissue penetration.

When should I choose VHH-Fc or bivalent formats?

Use VHH-Fc/bivalent for higher apparent affinity/half-life and plate/cell capture; choose monovalent for steric-sensitive epitopes or intracellular use.

Are these humanized?

Selected SKUs offer humanized frameworks or Fc fusions; see product page for sequence origin and species compatibility.

RUO disclaimer

All products are for Research Use Only and not for diagnostic or therapeutic procedures.

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