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Home > Products > Antibodies > XtenNano®Nanobodies

Nanobodies (VHH / Single-Domain Antibodies)

abinScience nanobodies (VHH, ~15 kDa) deliver high affinity and exceptional stability for blocking, imaging and capture workflows. Offered as monovalent VHH, bivalent/bispecific constructs and VHH-Fc fusions, with options for humanization, albumin-binding half-life extension, and conjugates (biotin/HRP/fluor). Produced in E. coli, HEK293 or CHO with lot-specific CoAs for purity, monomer %, endotoxin and activity. RUO

Why Researchers Choose abinScience

High-Affinity Panels Epitope & competition notes
Flexible Formats Monovalent, bivalent, VHH-Fc, albumin-binding
Multiple Hosts E. coli, HEK, CHO; low endotoxin
Ready Conjugates Biotin, HRP, Alexa Fluor 488/594/647
Lot-Specific QC Purity, monomer %, endotoxin, activity

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Selection Guide

  1. Use Case: Blocking (choose high-affinity, epitope-defined VHH) vs. imaging (small monovalent VHH or fluor-labeled).
  2. Valency/Fc: VHH-Fc or bivalent VHH increases avidity and half-life; monovalent reduces steric effects and improves penetration.
  3. Expression Host: E. coli for rapid screens; HEK/CHO for Fc fusions and glyco-dependent stability.
  4. Conjugation: Biotin/HRP for ELISA; Alexa 488/647 for IF/live-cell; keep free VHH for neutralization/MoA assays.
  5. Endotoxin & Monomer %: Check lot CoA (SEC-HPLC) for aggregation and endotoxin per sensitive cell assays.

Applications

Receptor/ligand blocking and virus neutralization studies
Live-cell tracing and super-resolution IF with minimal steric hindrance
Affinity capture, enrichment and immunopurification
SPR/BLI kinetics and biosensor construction

Documents & QC

CoA with purity, monomer %, endotoxin and activity method
SEC-HPLC/SDS-PAGE images; storage & reconstitution guidance

FAQs

What is a nanobody (VHH)?

A single-domain antibody derived from camelid heavy-chain-only antibodies; ~15 kDa, highly stable/soluble with excellent tissue penetration.

When should I choose VHH-Fc or bivalent formats?

Use VHH-Fc/bivalent for higher apparent affinity/half-life and plate/cell capture; choose monovalent for steric-sensitive epitopes or intracellular use.

Are these humanized?

Selected SKUs offer humanized frameworks or Fc fusions; see product page for sequence origin and species compatibility.

RUO disclaimer

All products are for Research Use Only and not for diagnostic or therapeutic procedures.

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