Please ensure Javascript is enabled for purposes of website accessibility
Contact us Contact Us
EN
Home > Products > Antibodies > XtenNano®Nanobodies

Nanobodies (VHH / Single-Domain Antibodies)

abinScience nanobodies (VHH, ~15 kDa) deliver high affinity and exceptional stability for blocking, imaging and capture workflows. Offered as monovalent VHH, bivalent/bispecific constructs and VHH-Fc fusions, with options for humanization, albumin-binding half-life extension, and conjugates (biotin/HRP/fluor). Produced in E. coli, HEK293 or CHO with lot-specific CoAs for purity, monomer %, endotoxin and activity. RUO

Why Researchers Choose abinScience

High-Affinity Panels Epitope & competition notes
Flexible Formats Monovalent, bivalent, VHH-Fc, albumin-binding
Multiple Hosts E. coli, HEK, CHO; low endotoxin
Ready Conjugates Biotin, HRP, Alexa Fluor 488/594/647
Lot-Specific QC Purity, monomer %, endotoxin, activity

Shop by Format

Shop by Application

Selection Guide

  1. Use Case: Blocking (choose high-affinity, epitope-defined VHH) vs. imaging (small monovalent VHH or fluor-labeled).
  2. Valency/Fc: VHH-Fc or bivalent VHH increases avidity and half-life; monovalent reduces steric effects and improves penetration.
  3. Expression Host: E. coli for rapid screens; HEK/CHO for Fc fusions and glyco-dependent stability.
  4. Conjugation: Biotin/HRP for ELISA; Alexa 488/647 for IF/live-cell; keep free VHH for neutralization/MoA assays.
  5. Endotoxin & Monomer %: Check lot CoA (SEC-HPLC) for aggregation and endotoxin per sensitive cell assays.

Applications

Receptor/ligand blocking and virus neutralization studies
Live-cell tracing and super-resolution IF with minimal steric hindrance
Affinity capture, enrichment and immunopurification
SPR/BLI kinetics and biosensor construction

Documents & QC

CoA with purity, monomer %, endotoxin and activity method
SEC-HPLC/SDS-PAGE images; storage & reconstitution guidance

FAQs

What is a nanobody (VHH)?

A single-domain antibody derived from camelid heavy-chain-only antibodies; ~15 kDa, highly stable/soluble with excellent tissue penetration.

When should I choose VHH-Fc or bivalent formats?

Use VHH-Fc/bivalent for higher apparent affinity/half-life and plate/cell capture; choose monovalent for steric-sensitive epitopes or intracellular use.

Are these humanized?

Selected SKUs offer humanized frameworks or Fc fusions; see product page for sequence origin and species compatibility.

RUO disclaimer

All products are for Research Use Only and not for diagnostic or therapeutic procedures.

Options+
Options
Confirm
  • Product types
    0 selected
    Antibodies (949)
    Research Biosimilar (19)
  • Expression system
    0 selected
    Mammalian Cells (20)
  • Target
    0 selected
    PTH1R (2)
    CD252/TNFSF4/OX40L (1)
    lgM (1)
    TRPC3 (1)
    HHRF3/US28 (5)
    CD18/ITGB2 (1)
    ADRB2 (3)
    DPP6 (1)
    Ricin (24)
    SOST (1)
    rev/ART/TRS (1)
    Gag polyprotein (3)
    F0 (1)
    HIF1A (2)
    nup54.S/Nup54 (1)
    CFP/Properdin (2)
    AMY2 (1)
    BACE2 (5)
    G protein (1)
    GPHN/Gephyrin (1)
    PA/pagA/PA-83 (1)
    Glycoprotein G1 (1)
    E6/Protein E6 (4)
    CD64/FCGR1A (2)
    IL12RB2 (1)
    NadA/Neisseria adhesin A (2)
    Complement C6 (1)
    FURIN (2)
    CADM3/NECL-1/TSLL1 (5)
    CD136/MST1R (1)
    6*His Tag (1)
    SLC5A8 (6)
    CD279/PD-1 (1)
    CD16a/FCGR3A (1)
    RNA-directed RNA polymerase/NSP9 (1)
    CD212/IL12RB1 (2)
    CFH (1)
    GCN4/AAS3 (1)
    LYZ/LysozymeC (1)
    LRP6 (2)
    CXCL11/I-TAC (8)
    VEGF/ANG-2 (1)
    C4b/Complement C4b (2)
    GP2 (1)
    ANGPT1 (1)
    gD/Envelope glycoprotein D (1)
    CD7 (1)
    NOTCH2 (1)
    MAGEB1 (3)
    TRIM28 (1)
    LYZ/Lysozyme C (7)
    ROR1/NTRKR1 (5)
    Capsid protein (6)
    EPEATag (2)
    gB (2)
    CDKN2A/p16INK4a (1)
    APOE (1)
    Capsid protein VP3 (1)
    gD (2)
    CD4 (1)
    CD32b/FCGR2B (1)
    AGTR1 (2)
    CD29/ITGB1 (1)
    EGFR/ERBB1 (8)
    CD11a/ITGAL (1)
    RNase A (1)
    G9 (2)
    ATP7B (3)
    PTK7 (1)
    5HT3/HTR3A (1)
    Fusion Protein (1)
    CD9 (2)
    Vif/SOR protein (1)
    CD182/CXCR2 (1)
    Albumin/HSA & IFNAR1/IFNAR2 (1)
    ADRB1 (5)
    stxB2/SLT-2b/VT2 (1)
    BCL2 (2)
    Tenuazonic acid (3)
    GST 26 (1)
    GAL-7/Galectin-7 (1)
    Glycoprotein E2 (1)
    NAP1L1 (1)
    Intact VWF (1)
    GPC3/Glypican3 (1)
    CD13/ANPEP/APN (11)
    CD3E (3)
    H2AX (2)
    Fab Fragment (1)
    CD8A (1)
    mAb-1E7 (1)
    BLM (3)
    CD184/CXCR4 (1)
    DLL3 (1)
    MSLN/Mesothelin (2)
    CD122/IL2RB (1)
    IFNG/IFN-gamma (1)
    SERPINE1/PAI-1 (5)
    CNR1/CB1 (4)
    NOTCH1 (1)
    CD124/IL4R (1)
    G-quadruplex DNA (1)
    PGF/PLGF (1)
    CD369/CLEC7A (1)
    APP/Amyloid beta (1)
    CD309/VEGFR-2 (1)
    CD40/TNFRSF5 (1)
    CD85a/LILRB3 (1)
    Toxin A/tcdA (2)
    TREM2 (4)
    trxA/Thioredoxin (1)
    IL12B/IL-12 p40 (1)
    G9&A16 complex (2)
    MLPH (1)
    M1R (1)
    PASM (1)
    ERBB3/HER3 (1)
    Phl p 6 (2)
    CD273/PD-L2/PDCD1LG2 (1)
    IL6 (2)
    HRH2 (1)
    CAVIN1 (1)
    Toxin B/tcdB (2)
    AX/Amoxicillin (3)
    ASC/TMS1/PYCARD (2)
    HTT (3)
    IgE/IGHE (1)
    TP53/p53 (2)
    lexA/LexA repressor (1)
    CD156b/ADAM17 (1)
    babA2 (1)
    higB-2 (7)
    CD31/PECAM1 (2)
    CD268/TNFRSF13C/BAFFR (1)
    PAD4 (1)
    VEGFA (2)
    ureB/Urease subunit beta (1)
    VHH (5)
    MET/HGFR (1)
    BC2 tag (1)
    CD156c/ADAM10 (1)
    CD337/NCR3/NKp30 (2)
    CD339/JAG1 (1)
    KRT19/CK19 (1)
    VSIG4/CRIg (8)
    CD3E & DLL3 & ALB (2)
    MUC16/CA-125 (1)
    FOLR1 (1)
    CD33 (1)
    dsRed (1)
    H2-Ab1/MHCII (6)
    Envelope protein E (1)
    CD209 (1)
    C3b/Complement C3b (1)
    NCL (1)
    CCT5 (1)
    p-γ-H2AX (1)
    IL17RB (1)
    CGA/CG-alpha (1)
    NSP2 (1)
    CD230/PRNP (2)
    FZD3 (2)
    E2 (1)
    C3/Complement C3 (2)
    CD49c/ITGA3 (1)
    CD38/ADPRC 1 (5)
    CD71/TFRC (2)
    Allergen Pis v 2/11S globulin (1)
    MC4R (2)
    TUFM (1)
    MAPT/Tau (4)
    Spike glycoprotein (87)
    Galectin-1 (1)
    GBA (1)
    CTNNB1 (4)
    CD126/IL6R (1)
    GP42/Glycoprotein 42 (2)
    CD217/IL17RA (1)
    RBD (4)
    RHOB (2)
    Albumin/Alb (1)
    GAK (1)
    CRMP1 (1)
    CD32/FcgR2 (1)
    CCL5/RANTES (1)
    ADAMTS13-cleaved VWF (1)
    PCSK9 (2)
    MAPK13 (1)
    CD112/Nectin-2/PVRL2 (2)
    ACTB/β-actin (1)
    PPIA (1)
    ARC (4)
    Kappa Chain (5)
    gp120/Glycoprotein 120 (6)
    CD137/4-1BB (1)
    CD274/PD-L1 (12)
    CD19 (2)
    Microcystin-LR (2)
    TNFα (2)
    FOS (1)
    Mal f 1/Allergen Pit o 1 (16)
    tetX/Tetanus toxin (1)
    Nucleoprotein (1)
    botA (4)
    CD223/LAG3 (3)
    CALCA/Calcitonin (1)
    TMPRSS2 (1)
    VWF (4)
    ANGPTL4 (1)
    SNCA/Alpha-synuclein (1)
    Bet v 1/Allergen Bet v I-A (3)
    CASP3/Caspase-3 (3)
    CTGF/CCN2 (1)
    short-chain α-neurotoxin (1)
    CFTR (7)
    CXCL12/SDF-1 (1)
    IL23A (1)
    E7/ProteinE7 (1)
    PTH (1)
    entB/SEB (1)
    SV2A (1)
    E7/Protein E7 (4)
    CD154/CD40L (1)
    Nav1.4 (2)
    VRG4 (2)
    Nup54 (1)
    MMP12 (1)
    A29L (16)
    F (1)
    COL1A1 (1)
    CXCR7/ACKR3 (1)
    Lambda light chain (1)
    CD86/B7-2 (2)
    PTCH1 (3)
    MTX/Methotrexate (2)
    CD156a/ADAM8 (1)
    KLB/Beta-klotho (2)
    ureC/glmM (1)
    CD284/TLR4 (1)
    SLC5A1 (1)
    GST (1)
    F/Fusion glycoprotein F0 (10)
    IgM (1)
    TNFa/TNF-alpha (4)
    CD66e/CEA (4)
    ASIC1 (1)
    B2M/β2M (2)
    Shiga toxin 2 subunit B/stx2eB (2)
    AFB1/Aflatoxin B1 (1)
    CPB2/TAFI (5)
    MDM4 (1)
    CD326/EPCAM (1)
    FOLH1/PSMA (1)
    STAT3 (1)
    CD89/FCAR (1)
    LYZ (4)
    PSIP1 (1)
    CD72 (1)
    CD49e/ITGA5 (1)
    CX3CR1 (2)
    CD197/CCR7 (1)
    AKT1 (2)
    OPRM1/μOR (1)
    S/Spike glycoprotein (2)
    DLL4 (1)
    GSN/Gelsolin (4)
    F11/Coagulation factor XI (1)
    NOTCH3 (1)
    NP/Nucleoprotein (15)
    2 (2)
    LSP1 (1)
    LGR4 (1)
    xcpQ (1)
    ISG15 (2)
    Albumin/HSA (4)
    Capsid protein VP1 (1)
    PSA/KLK3 (1)
    MERS-CoV RBD (1)
    RAGE-1/MOK (2)
    ctxB/Cholera Toxin Subunit B (2)
    botA/BoNT (3)
    AZT/Aztreonam (2)
    CD3E & Mesothelin & ALB (1)
    CASR (1)
    ACKR1/CD234 (1)
    AKT3 (1)
    Nav1.5 (2)
    GPR183 (1)
    GP6/GPVI (1)
    PLAU (1)
    AaH II/Neurotoxin II (4)
    CD202b/TEK/TIE-2 (1)
    CD366/TIM-3 (2)
    CD16/FcgR3 (1)
    DKK1 (2)
    AURKA (1)
    mCherry (3)
    EPHB6 (1)
    CD28 (1)
    BAX (2)
    WFDC2/HE4 (1)
    ALFA tag (1)
    DRD2 (6)
    IL23R (3)
    Protein P (2)
    PLAC1 (3)
    CD269/BCMA (1)
    ADAMTS5 (2)
    CLDN18.2 (1)
    Enhanced GFP (1)
    CD120a/TNFR1 (4)
    CD331/FGFR1 (1)
    CD370/CLEC9A (7)
    CCL2/MCP-1 (1)
    CD254/RANKL/TNFSF11 (1)
    RECQL5 (9)
    GFAP (2)
    TACSTD2/TROP2 (1)
    babA (1)
    GFP (5)
    CD11b/ITGAM (6)
    MMP13 (1)
    GPC3/Glypican 3 (1)
    OLR1/LOX-1 (1)
    HTR2A (1)
    EPOR (2)
    CEP164 (2)
    IRSp53/BAIAP2 (1)
    CD123/IL-3Rα (1)
    GRM5 (2)
    4-D (2)
    GP/Glycoprotein (1)
    TG/Thyroglobulin (2)
    OPRK1 (1)
    RNA-directed RNA polymerase L/ProteinL (1)
    GABRB3 (1)
    CRP (2)
    Betv1/Allergen Bet v 1-A (1)
    LMO2 (2)
    MoonTag (1)
    ompA (2)
    PIGR (1)
    Fusion glycoprotein F0 (1)
    EPHX2 (1)
    IL17F (1)
    CD135/FLT3 (1)
    C5/Complement C5 (1)
    CD132/IL2RG (1)
    GPR68 (1)
    Trastuzumab (1)
    IgG1 Fc Fragment (1)
    BIRC5 (1)
    CD114/CSF3R (1)
    CD275/ICOSLG (1)
    SLC4A7 (1)
    CHRM2 (2)
    CD45/PTPRC (8)
    MLANA (1)
    CD276/B7-H3 (1)
    CD152/CTLA4 (8)
    CD66c/CEACAM6 (2)
    VIM/Vimentin (1)
    stxB/SLT-1b/VT1 (2)
    SYNJ1 (2)
    CD47/MER6 (6)
    HBEGF (1)
    CD206/MRC1 (6)
    GABRA1 (1)
    SLC10A1 (3)
    CD262/TRAIL-R2/DR5 (3)
    CD340/ERBB2 (5)
    BACE1 (1)
    CDw210b/IL10RB (10)
    DCX (2)
    Nucleoporin Nup58/54/62 (1)
    TRPM4/LTRPC4 (1)
    porM (4)
    TK1 (1)
    APLNR/APJ (2)
    CDH17/Cadherin-17 (2)
    CCL3/MIP-1-alpha (2)
    A2AR/ADORA2A (1)
    Phl p 4 (1)
    ANGPT4 (1)
    CAT/Catalase (1)
    CD158a/KIR2DL1 (1)
    InlB/Internalin B (2)
    TTYH2 (1)
    KCNA3 (1)
    nef/F-protein/Negative factor (1)
    SOD1 (1)
    BoNT/B (5)
    Genome polyprotein (1)
    Alpha-cobratoxin (1)
    RNA polymerase complex (2)
    GRM2 (1)
    B2M/β2-MG (1)
    CD14 (1)
    CD332/FGFR2 (1)
    CD106/VCAM1 (2)
    ADAM9 (1)
    CD282/TLR2 (2)
    CD16b/FCGR3B (3)
    CD70 (1)
    CD163 (1)
    Adiponectin/ADPN (1)
    CD5/Ly-1 (3)
    ANGPT2/ANG-2 (1)
    CD20/MS4A1 (1)
    CD1d (1)
    botA/BOTOX (20)
    CD167b/DDR2 (1)
    AaH I/Neurotoxin I (1)
    ADAM12 (2)
    CD221/IGF1R (1)
    wlaB/pglK (1)
    Envelopeglycoprotein E2/gp55 (3)
    SP140 (1)
  • Species
    0 selected
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (1)
    Human immunodeficiency virus 1 (HIV-1) (1)
    Mouse (3)
    Human respiratory syncytial virus (HRSV) (3)
    Poliovirus type 1 (PV1) (1)
    Human (22)
    Campylobacter jejuni subsp. (1)
    Human cytomegalovirus (HCMV/HHV-5) (1)
  • Applications
    0 selected
    Bioactivity: FACS (19)
    IHC (17)
    EMSA (1)
    Functional assay (19)
    Isotype Control (5)
    IP (38)
    Neutralization (42)
    BLI (1)
    Research in vivo (19)
    Inhibition (3)
    FuncS (13)
    FCM (201)
    IF (79)
    Blocking (16)
    RIA (16)
    BIF (7)
    in vivo neutralization (1)
    ELISA (902)
    DB (5)
    Cyro-EM (1)
    WB (92)
    Agonist (1)
    X-ray Crystallography (1)
    SPR (113)
  • Reactivity
    0 selected
    Poliovirus type 1 (PV1) (1)
    HSV-2 (4)
    Bovine (1)
    Nipah virus (1)
    Alternaria species. (3)
    Blood fluke (1)
    Classical swine fever virus (CSFV) (2)
    Cynomolgus (8)
    Bacteriophage 933W (1)
    Clostridioides difficile (4)
    E. coli (4)
    Vaccinia virus (VACV) (4)
    Helicobacter pylori (4)
    Discosoma sp. LW-2004 (1)
    Human immunodeficiency virus 1 (HIV-1) (11)
    Chikungunya virus (1)
    Vesicular stomatitis Indiana virus (VSIV) (3)
    Pistachio (1)
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (93)
    Zika Virus (1)
    Epstein-Barr virus (EBV/HHV-4) (2)
    Human (494)
    Microcystis aeruginosa (2)
    Wild turkey (1)
    Malassezia furfur (16)
    Clostridium tetani (1)
    Junin mammarenavirus (1)
    European white birch (4)
    Staphylococcus aureus (1)
    Human papillomavirus 16 (HPV16) (9)
    Candida albicans (2)
    Monkeypox virus (MPXV) (16)
    HPIV-3 (1)
    Canis lupus familiaris (Dog) (2)
    Cynomolgus monkey (1)
    Schistosoma japonicum (Blood fluke) (1)
    Mouse (65)
    Severe acute respiratory syndrome coronavirus (SARS-CoV) (2)
    Vesicular stomatitis Indiana virus (3)
    Pseudomonas aeruginosa (1)
    MERS-CoV (1)
    Vibrio cholerae (9)
    Pig (7)
    Bacillus cereus (1)
    Parainfluenza virus 5 (PIV5) (2)
    Water jellyfish (6)
    Influenza A virus (Flu A) (6)
    Zaire ebolavirus (ZEBOV) (1)
    Human respiratory syncytial virus (HRSV) (6)
    Human cytomegalovirus (HCMV/HHV-5) (4)
    Escherichia coli (2)
    Nipah virus (NiV) (1)
    Human metapneumovirus (HMPV) (2)
    Bacteriophage H19B (2)
    Porphyromonas gingivalis (4)
    Rat (3)
    Phleum pratense (Common timothy) (3)
    Listeria monocytogenes (2)
    Hepatitis C Virus (HCV) (1)
    Naja kaouthia (1)
    Sudan ebolavirus (SEBOV) (2)
    Clostridium botulinum (32)
    Sahara scorpion (5)
    Bovine viral diarrhea virus (BVDV) (3)
    Anaplasma marginale (2)
    Castor bean (24)
    HSV-1 (4)
    African clawed frog (3)
    Hendra virus (1)
    Bacillus anthracis (2)
    Oropouche virus (1)
    Neisseria meningitidis (2)
    Porcine reproductive and respiratory syndrome virus (PRRSV) (2)
    Baker's yeast (1)
    Chicken (7)
    Norwalk virus (1)
    Human herpesvirus 1 (HSV-1/HHV-1) (1)
    Norwalk virus (NV) (5)
    General (13)
  • Host species
    0 selected
    Mouse (123)
    Human (128)
    Alpaca (705)
    Rat (5)
  • Clonality
    0 selected
    Monoclonal (968)
  • Conjugate
    0 selected
    APC (20)
    PerCP (20)
    PE (21)
    Unconjugated (885)
    FITC (21)

Quick access

Contact Us

  • +86-027-65523339

  • info@abinscience.com

  • Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China

Copyright © 2025 abinScience. All Rights Reserved. All Products are for Research Use Only